The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.
The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.
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DOI：
10.1007/s11892-018-1113-2
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发表时间：
2018-10-23
影响因子：
4.2
通讯作者：
TEDDY Study Group
中科院分区：
文献类型：
--
作者：
Rewers M;Hyöty H;Lernmark Å;Hagopian W;She JX;Schatz D;Ziegler AG;Toppari J;Akolkar B;Krischer J;TEDDY Study Group
需要阐明导致1型糖尿病(T1D)的胰岛自身免疫的环境触发因素，以告知初级预防。青年糖尿病的环境决定因素(Teddy)研究跟踪了美国、芬兰、德国和瑞典的8676名具有T1D风险的人类白细胞抗原-DR-DQ基因的儿童。多数受试者(%)与T1D无一级亲属关系。主要结果包括出现一种或多种持续性胰岛自身抗体(胰岛自身免疫，IA)和临床T1D。截至2018年2月28日，769名儿童患上IA，310名儿童进展到T1D。次要结果包括乳糜泻和自身免疫性甲状腺疾病。随着后续行动的继续，泰迪已经评估了一些候选的环境触发因素，包括感染、益生菌、微量营养素和微生物组。泰迪的研究结果表明，有多种途径可以导致胰岛β细胞的破坏。正在进行的进一步特定暴露、基因变异和基因-环境相互作用的测量以及详细的“组学”研究将为T1D的发病机制提供新的信息。
The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. As of February 28,2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed “omics” studies will provide novel information on the pathogenesis of T1D.
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影响因子：
3.2
作者：
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作者：
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3.7
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通讯作者：
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影响因子：
2.2
作者：
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通讯作者：
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