Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions.
Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions.
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DOI：
10.1038/s41398-021-01629-8
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发表时间：
2021-09-30
影响因子：
6.8
通讯作者：
Lu L
中科院分区：
文献类型：
--
作者：
Han Y;Yuan K;Wang Z;Liu WJ;Lu ZA;Liu L;Shi L;Yan W;Yuan JL;Li JL;Shi J;Liu ZC;Wang GH;Kosten T;Bao YP;Lu L
2019冠状病毒病（COVID-19）大流行造成了大规模的经济和社会损失以及全球死亡人数。尽管大多数COVID-19患者最初主诉呼吸功能不全，但也经常报告存在神经精神症状，包括头痛、嗅觉减退/嗅觉丧失和神经肌肉功能障碍，以及中风、癫痫发作、脑病、精神状态改变和精神疾病，无论是在急性期还是长期。这些神经精神并发症已成为临床结局恶化和预后不良的潜在指标，从而导致COVID-19患者的死亡率。其病因仍不清楚，可能涉及多种神经侵袭途径。在这里，我们总结了最近的动物和人类的研究严重急性呼吸综合征冠状病毒（SARS-CoV-2）的神经营养特性，并阐明了潜在的神经致病机制参与病毒入侵中枢神经系统的脑损伤和神经功能障碍的原因。然后，我们讨论了干预和预防与SARS-CoV-2感染相关的神经精神并发症的潜在治疗策略。需要在暴露于SARS-CoV-2的个体中实施对神经精神和神经免疫并发症的临床-神经化学-放射学进展的时间序列监测。迫切需要开发一种筛查、干预和治疗框架来预防和减少神经精神后遗症，这对于COVID-19患者的短期和长期康复至关重要。
The coronavirus disease 2019 (COVID-19) pandemic has caused large-scale economic and social losses and worldwide deaths. Although most COVID-19 patients have initially complained of respiratory insufficiency, the presence of neuropsychiatric manifestations is also reported frequently, ranging from headache, hyposmia/anosmia, and neuromuscular dysfunction to stroke, seizure, encephalopathy, altered mental status, and psychiatric disorders, both in the acute phase and in the long term. These neuropsychiatric complications have emerged as a potential indicator of worsened clinical outcomes and poor prognosis, thus contributing to mortality in COVID-19 patients. Their etiology remains largely unclear and probably involves multiple neuroinvasive pathways. Here, we summarize recent animal and human studies for neurotrophic properties of severe acute respiratory syndrome coronavirus (SARS-CoV-2) and elucidate potential neuropathogenic mechanisms involved in the viral invasion of the central nervous system as a cause for brain damage and neurological impairments. We then discuss the potential therapeutic strategy for intervening and preventing neuropsychiatric complications associated with SARS-CoV-2 infection. Time-series monitoring of clinical–neurochemical–radiological progress of neuropsychiatric and neuroimmune complications need implementation in individuals exposed to SARS-CoV-2. The development of a screening, intervention, and therapeutic framework to prevent and reduce neuropsychiatric sequela is urgently needed and crucial for the short- and long-term recovery of COVID-19 patients.
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影响因子：
13.6
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影响因子：
3
作者：
Chen, Wendy;Toprani, Sheela;Falco-Walter, Jessica
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10.1016/s2352-4642(21)00050-x
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作者：
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