The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains.
The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains.
复制标题
人和小鼠大脑中 SARS-CoV-2 受体 ACE2 的空间和细胞类型分布。
DOI：
10.3389/fneur.2020.573095
复制
发表时间：
2020
影响因子：
3.4
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Chen R;Wang K;Yu J;Howard D;French L;Chen Z;Wen C;Xu Z
新型致病性严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）通过与血管紧张素转换酶2（ACE 2或Ace 2）结合，侵入宿主细胞并影响包括大脑在内的许多器官。然而，ACE 2在脑中的分布仍然不清楚。在这里，我们通过分析来自公开可用的脑转录组数据库的数据来研究ACE 2在脑中的表达。根据空间分布分析，ACE 2在某些脑组织中表达相对较高，如脉络丛和室旁核。根据细胞类型分布分析，ACE 2的核表达被发现在许多神经元（兴奋性和抑制性神经元）和一些非神经元细胞（主要是星形胶质细胞，少突胶质细胞和内皮细胞）在人颞中回和后扣带回皮质。在海马数据集中发现了一些ACE 2表达核，在前额叶皮层中没有检测到。Ace 2在小鼠脑中的分布与人脑中的分布相似，除了在嗅球区域的空间分布以及在周细胞和内皮细胞的细胞类型分布中的额外高表达外。因此，我们的研究结果揭示了ACE 2/Ace 2在人类和小鼠大脑中的分布概况，这表明SARS-CoV-2的大脑感染可能能够诱导2019冠状病毒病（COVID-19）患者的中枢神经系统症状。在使用小鼠模型研究SARS-CoV-2感染的神经效应时，应考虑潜在的物种差异。
By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells and affects many organs, including the brain. However, the distribution of ACE2 in the brain is still obscure. Here, we investigated the ACE2 expression in the brain by analyzing data from publicly available brain transcriptome databases. According to our spatial distribution analysis, ACE2 was relatively highly expressed in some brain locations, such as the choroid plexus and paraventricular nuclei of the thalamus. According to cell-type distribution analysis, nuclear expression of ACE2 was found in many neurons (both excitatory and inhibitory neurons) and some non-neuron cells (mainly astrocytes, oligodendrocytes, and endothelial cells) in the human middle temporal gyrus and posterior cingulate cortex. A few ACE2-expressing nuclei were found in a hippocampal dataset, and none were detected in the prefrontal cortex. Except for the additional high expression of Ace2 in the olfactory bulb areas for spatial distribution as well as in the pericytes and endothelial cells for cell-type distribution, the distribution of Ace2 in the mouse brain was similar to that in the human brain. Thus, our results reveal an outline of ACE2/Ace2 distribution in the human and mouse brains, which indicates that the brain infection of SARS-CoV-2 may be capable of inducing central nervous system symptoms in coronavirus disease 2019 (COVID-19) patients. Potential species differences should be considered when using mouse models to study the neurological effects of SARS-CoV-2 infection.
登录
查看更多内容
影响因子：
4.4
作者：
Gonzalez-Castellano, Ines;Manfrin, Chiara;Martinez-Lage, Andres
通讯作者：
Martinez-Lage, Andres
影响因子：
9.8
作者：
He L;Vanlandewijck M;Mäe MA;Andrae J;Ando K;Del Gaudio F;Nahar K;Lebouvier T;Laviña B;Gouveia L;Sun Y;Raschperger E;Segerstolpe Å;Liu J;Gustafsson S;Räsänen M;Zarb Y;Mochizuki N;Keller A;Lendahl U;Betsholtz C
通讯作者：
Betsholtz C
影响因子：
48
作者：
Habib N;Avraham-Davidi I;Basu A;Burks T;Shekhar K;Hofree M;Choudhury SR;Aguet F;Gelfand E;Ardlie K;Weitz DA;Rozenblatt-Rosen O;Zhang F;Regev A
通讯作者：
Regev A
多器官感染和SAR的发病机理。
影响因子：
15.3
作者：
Gu, Jiang;Gong, Encong;Zhang, Bo;Zheng, Jie;Gao, Zifen;Zhong, Yanfeng;Zou, Wanzhong;Zhan, Jun;Wang, Shenglan;Xie, Zhigang;Zhuang, Hui;Wu, Bingquan;Zhong, Haohao;Shao, Hongquan;Fang, Weigang;Gao, Dongshia;Pei, Fei;Li, Xingwang;He, Zhongpin;Xu, Danzhen;Shi, Xeying;Anderson, Virginia M;Leong, Anthony S-Y
通讯作者：
Leong, Anthony S-Y
DOI：
10.1126/science.1262110
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
GTEx Consortium
通讯作者：
GTEx Consortium