Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population.
Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population.
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DOI：
10.1111/cas.12369
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发表时间：
2014-04
期刊：
影响因子：
5.7
通讯作者：
Inohara H
中科院分区：
文献类型：
--
作者：
Maruyama H;Yasui T;Ishikawa-Fujiwara T;Morii E;Yamamoto Y;Yoshii T;Takenaka Y;Nakahara S;Todo T;Hongyo T;Inohara H
我们的目的是揭示日本头颈部鳞状细胞癌（HNSCC）患者中人乳头瘤病毒（HPV）感染和p53突变的患病率和模式与临床病理参数的关系。检测493例HNSCC及其亚群283例HNSCC中人乳头瘤病毒DNA和p53突变。口咽癌组织中HPV阳性率为34.4%，明显高于非口咽癌组织（3.6%，P < 0.001），其中HPV 16型占91.1%。在口咽癌中，HPV感染率随时间呈上升趋势（P < 0.001），HPV感染与吸烟、饮酒、p53突变和破坏性突变呈负相关（分别为P = 0.003、<0.001、<0.001和<0.001）。病毒无关的HNSCC与病毒相关的HNSCC（包括鼻咽癌和HPV阳性的口咽癌）之间p53突变的发生率有显著性差异（48.3%vs7.1%，P < 0.001）。虽然p53突变与吸烟和饮酒有关，但这种关联在病毒无关的HNSCC中消失。在病毒相关的HNSCC中从未发现破坏性突变，而在病毒无关的HNSCC中，该突变与原发部位如口咽和下咽独立相关（分别为P = 0.01和0.03）。此外，在病毒无关的HNSCC中，G：C到T：A的转换在吸烟者中比从不吸烟者更频繁（P = 0.04），而在CpG位点的G：C到A：T的转换在吸烟者中比从不吸烟者更不频繁（P = 0.04）。总之，HNSCC在病因学上分为病毒相关和病毒无关亚组。在病毒相关的HNSCC中，p53突变是罕见的，没有破坏性突变，而在病毒无关的HNSCC中，p53突变是常见的，并且p53的破坏性突变与口咽癌和下咽癌有关。
We aimed to reveal the prevalence and pattern of human papillomavirus (HPV) infection and p53 mutations among Japanese head and neck squamous cell carcinoma (HNSCC) patients in relation to clinicopathological parameters. Human papillomavirus DNA and p53 mutations were examined in 493 HNSCCs and its subset of 283 HNSCCs. Oropharyngeal carcinoma was more frequently HPV-positive than non-oropharyngeal carcinoma (34.4% vs 3.6%, P < 0.001), and HPV16 accounted for 91.1% of HPV-positive tumors. In oropharyngeal carcinoma, which showed an increasing trend of HPV prevalence over time (P < 0.001), HPV infection was inversely correlated with tobacco smoking, alcohol drinking, p53 mutations, and a disruptive mutation (P = 0.003, <0.001, <0.001, and <0.001, respectively). The prevalence of p53 mutations differed significantly between virus-unrelated HNSCC and virus-related HNSCC consisting of nasopharyngeal and HPV-positive oropharyngeal carcinomas (48.3% vs 7.1%, P < 0.001). Although p53 mutations were associated with tobacco smoking and alcohol drinking, this association disappeared in virus-unrelated HNSCC. A disruptive mutation was never found in virus-related HNSCC, whereas it was independently associated with primary site, such as the oropharynx and hypopharynx (P = 0.01 and 0.03, respectively), in virus-unrelated HNSCC. Moreover, in virus-unrelated HNSCC, G:C to T:A transversions were more frequent in ever-smokers than in never-smokers (P = 0.04), whereas G:C to A:T transitions at CpG sites were less frequent in ever-smokers than in never-smokers (P = 0.04). In conclusion, HNSCC is etiologically classified into virus-related and virus-unrelated subgroups. In virus-related HNSCC, p53 mutations are uncommon with the absence of a disruptive mutation, whereas in virus-unrelated HNSCC, p53 mutations are common, and disruptive mutagenesis of p53 is related with oropharyngeal and hypopharyngeal carcinoma.
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影响因子：
56.9
作者：
CHO, YJ;GORINA, S;PAVLETICH, NP
通讯作者：
PAVLETICH, NP
DOI：
10.1086/597755
发表时间：
2009-05-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
D'Souza G;Agrawal Y;Halpern J;Bodison S;Gillison ML
通讯作者：
Gillison ML
影响因子：
11.2
作者：
Le Calvez, F;Mukeria, A;Hainaut, P
通讯作者：
Hainaut, P
影响因子：
158.5
作者：
Poeta, M. Luana;Manola, Judith;Koch, Wayne M.
通讯作者：
Koch, Wayne M.
DOI：
10.1097/00004347-199804000-00009
发表时间：
1998-04-01
影响因子：
2.4
作者：
Kalantari, M;Karlsen, F;Johansson, B
通讯作者：
Johansson, B