Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system.
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system.
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DOI：
10.1083/jcb.200809008
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发表时间：
2009-04-06
期刊：
影响因子：
--
通讯作者：
Relvas JB
中科院分区：
文献类型：
--
作者：
Pereira JA;Benninger Y;Baumann R;Gonçalves AF;Ozçelik M;Thurnherr T;Tricaud N;Meijer D;Fässler R;Suter U;Relvas JB
在发育过程中，雪旺细胞（SC）解释不同的细胞外信号来调节其迁移，增殖，以及与轴突的分选，鞘化和髓鞘形成相关的显着形态学变化。虽然细胞外基质蛋白和整合素之间的相互作用是至关重要的一些这些过程中，它们控制的下游信号通路仍然知之甚少。整合素连接激酶（ILK）是一种粘着斑蛋白，其与多个结合伴侣结合以将整合素连接到肌动蛋白细胞骨架，并且被认为参与整合素和生长因子介导的信号传导。使用SC特异性基因消融，我们报告了ILK在周围神经系统轴突束径向分选和髓鞘再生中的重要功能。我们的体内和体外实验表明，ILK负调控Rho/Rho激酶信号，以促进SC过程的延伸和启动径向分选。ILK还可能通过促进下游分子如AKT/蛋白激酶B的活化来促进轴突髓鞘再生。
During development, Schwann cells (SCs) interpret different extracellular cues to regulate their migration, proliferation, and the remarkable morphological changes associated with the sorting, ensheathment, and myelination of axons. Although interactions between extracellular matrix proteins and integrins are critical to some of these processes, the downstream signaling pathways they control are still poorly understood. Integrin-linked kinase (ILK) is a focal adhesion protein that associates with multiple binding partners to link integrins to the actin cytoskeleton and is thought to participate in integrin and growth factor–mediated signaling. Using SC-specific gene ablation, we report essential functions for ILK in radial sorting of axon bundles and in remyelination in the peripheral nervous system. Our in vivo and in vitro experiments show that ILK negatively regulates Rho/Rho kinase signaling to promote SC process extension and to initiate radial sorting. ILK also facilitates axon remyelination, likely by promoting the activation of downstream molecules such as AKT/protein kinase B.
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影响因子：
3.5
作者：
Leone, DP;Genoud, S;Suter, U
通讯作者：
Suter, U
影响因子：
14.9
作者：
Indra, AK;Warot, X;Metzger, D
通讯作者：
Metzger, D
影响因子：
64.8
作者：
Li, M;Indra, AK;Chambon, P
通讯作者：
Chambon, P
DOI：
10.1083/jcb.200109021
发表时间：
2002-01-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Feltri ML;Graus Porta D;Previtali SC;Nodari A;Migliavacca B;Cassetti A;Littlewood-Evans A;Reichardt LF;Messing A;Quattrini A;Mueller U;Wrabetz L
通讯作者：
Wrabetz L
影响因子：
7.7
作者：
Grashoff, C;Aszódi, A;Fässler, R
通讯作者：
Fässler, R