Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings.
Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings.
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DOI：
10.1111/epi.13510
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发表时间：
2016-10
期刊：
影响因子：
5.6
通讯作者：
Morgan VL
中科院分区：
文献类型：
--
作者：
Englot DJ;Konrad PE;Morgan VL
癫痫是最常见的脑网络疾病之一，它与大量的发病率和死亡率增加有关。虽然局灶性癫痫在传统上被认为是一种区域性脑疾病，但越来越多的证据表明，这种疾病中广泛的网络改变超出了癫痫发作起源的致痫区。本综述的目的是总结最近的调查研究局灶性癫痫的功能和结构连接的改变，包括神经影像学和电生理学研究，利用基于模型或数据驱动的分析方法。在内侧颞叶癫痫和局灶性新皮质癫痫的研究中，一个重要的子集已经证明了与致痫区相关的连接增加的模式，以及广泛的远端网络连接减少的模式。连接模式似乎与疾病的持续时间和严重程度有关，表明随着时间的推移，在反复发作的背景下进行性连接重组。局灶性癫痫的整体静息状态连接障碍与神经认知问题有关，包括记忆和语言障碍。虽然特定脑区的连接性增加可能会增强癫痫发作的倾向，但尚不清楚连接性的整体减少是否代表复发性癫痫发作的破坏性后果，或防止癫痫发作传播远离致痫区的适应性机制。总体而言，研究局灶性癫痫的连接体是一个关键的奋进，这可能会导致癫痫区定位，手术结果预测，更好地了解复发性癫痫发作的神经心理学影响的改进策略。
Epilepsy is among the most common brain network disorders, and it is associated with substantial morbidity and increased mortality. While focal epilepsy was traditionally thought of as a regional brain disorder, growing evidence has demonstrated widespread network alterations in this disorder which extend beyond the epileptogenic zone from which seizures originate. The goal of this review is to summarize recent investigations examining functional and structural connectivity alterations in focal epilepsy, including neuroimaging and electrophysiology studies utilizing model-based or data-driven analysis methods. A significant subset of studies in both mesial temporal lobe epilepsy and focal neocortical epilepsy have demonstrated patterns of increased connectivity related to the epileptogenic zone, coupled with decreased connectivity in widespread distal networks. Connectivity patterns appear to be related to the duration and severity of disease, suggesting progressive connectivity reorganization in the setting of recurrent seizures over time. Global resting-state connectivity disturbances in focal epilepsy have been linked to neurocognitive problems, including memory and language disturbances. While it is possible that increased connectivity in a particular brain region may enhance the propensity for seizure generation, it is not clear if global reductions in connectivity represent the damaging consequences of recurrent seizures, or an adaptive mechanism to prevent seizure propagation away from the epileptogenic zone. Overall, studying the connectome in focal epilepsy is a critical endeavor which may lead to improved strategies for epileptogenic zone localization, surgical outcome prediction, and a better understanding of the neuropsychological implications of recurrent seizures.
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影响因子：
5.6
作者：
Furman M;Zhan Q;McCafferty C;Lerner BA;Motelow JE;Meng J;Ma C;Buchanan GF;Witten IB;Deisseroth K;Cardin JA;Blumenfeld H
通讯作者：
Blumenfeld H
影响因子：
3.4
作者：
Constable RT;Scheinost D;Finn ES;Shen X;Hampson M;Winstanley FS;Spencer DD;Papademetris X
通讯作者：
Papademetris X
影响因子：
4.8
作者：
Doucet, Gaelle;Osipowicz, Karol;Sharan, Ashwini;Sperling, Michael R.;Tracy, Joseph I.
通讯作者：
Tracy, Joseph I.
影响因子：
2.2
作者：
Englot, Dario J.;Nagarajan, Srikantan S.;Kirsch, Heidi E.
通讯作者：
Kirsch, Heidi E.
DOI：
10.1523/jneurosci.3846-09.2009
发表时间：
2009-10-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Englot DJ;Modi B;Mishra AM;DeSalvo M;Hyder F;Blumenfeld H
通讯作者：
Blumenfeld H