High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers.
High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers.
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DOI：
10.1038/s41598-017-18796-8
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发表时间：
2018-01-11
影响因子：
4.6
通讯作者：
Seino KI
中科院分区：
文献类型：
--
作者：
Baghdadi M;Endo H;Takano A;Ishikawa K;Kameda Y;Wada H;Miyagi Y;Yokose T;Ito H;Nakayama H;Daigo Y;Suzuki N;Seino KI
尽管近年来肺癌的诊断和治疗取得了进展，但5年生存率仍不令人满意，这需要识别与疾病进展和恶性程度相关的新因素，以改进诊断和治疗策略。癌症免疫学研究的最新进展揭示了集落刺激因子1受体（CSF 1 R）在肿瘤微环境的多个方面的关键作用。CSF 1 R在肿瘤相关巨噬细胞（TAM）上表达，并介导重要的促肿瘤发生功能。CSF 1 R还提供促进癌细胞存活和增殖的关键自分泌信号。CSF 1 R的激活可以通过两种独立的配体实现：巨噬细胞集落刺激因子（M-CSF）和白细胞介素34（IL-34）。因此，预期这些配体在癌症中的表达会导致不良预后。在这项研究中，我们发现IL-34和M-CSF表达与肺癌患者队列中的生存率低相关。重要的是，IL-34和M-CSF的高共表达与显示两种配体的弱表达或不表达的癌症相比，与最差的存活相关。此外，IL-34和M-CSF的高表达与肺癌的晚期相关。总之，这些结果表明IL-34/M-CSF表达与肺癌患者的不良生存和疾病进展之间存在相关性。
Despite recent advances in diagnosis and treatment of lung cancers, the 5-year survival rate remains unsatisfactory, which necessitates the identification of novel factors that associates with disease progression and malignant degree for improving diagnostic and therapeutic strategies. Recent progress in cancer immunology research has unveiled critical roles for colony stimulating factor 1 receptor (CSF1R) in multiple aspects of the tumor microenvironment. CSF1R is expressed on tumor-associated macrophages (TAMs), and mediates important pro-tumorigenic functions. CSF1R also provides critical autocrine signals that promote cancer cell survival and proliferation. Activation of CSF1R can be achieved by two independent ligands; macrophage colony-stimulating factor (M-CSF) and interleukin 34 (IL-34). Accordingly, the expression of these ligands in cancer is expected to result in poor prognosis. In this study, we show that IL-34 and M-CSF expression correlates with poor survival in a cohort of lung cancer patients. Importantly, high co-expression of IL-34 and M-CSF associates with the poorest survival compared to cancers that show weak or absent expression of the two ligands. Furthermore, high expression of IL-34 and M-CSF associates with advanced stages of lung cancers. Together, these results indicate a correlation between IL-34/M-CSF expression with poor survival and disease progression in lung cancer patients.
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影响因子：
45.3
作者：
Eberhard, DA;Johnson, BE;Hillan, KJ
通讯作者：
Hillan, KJ
影响因子：
6.4
作者：
Maniecki, Maciej Bogdan;Etzerodt, Anders;Moller, Holger Jon
通讯作者：
Moller, Holger Jon
影响因子：
45.3
作者：
Bepler, Gerold;Kusmartseva, Irina;Simon, George
通讯作者：
Simon, George
影响因子：
9
作者：
Cioce M;Canino C;Goparaju C;Yang H;Carbone M;Pass HI
通讯作者：
Pass HI
影响因子：
32.4
作者：
Noy, Roy;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.