Fragile skin microbiomes in megacities are assembled by a predominantly niche-based process.
Fragile skin microbiomes in megacities are assembled by a predominantly niche-based process.
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DOI：
10.1126/sciadv.1701581
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发表时间：
2018-03
期刊：
影响因子：
13.6
通讯作者：
Sul WJ
中科院分区：
文献类型：
--
作者：
Kim HJ;Kim H;Kim JJ;Myeong NR;Kim T;Park T;Kim E;Choi JY;Lee J;An S;Sul WJ
大城市皮肤微生物群的主要基于生态位的过程组装导致相对脆弱的微生物网络。鉴于城市化人口中皮肤病的发病率较高及其与皮肤微生物群的关系，我们质疑皮肤微生物群如何根据城市化程度而有所不同。中国五个大城市的 231 名健康受试者的皮肤微生物组差异主要取决于相关城市的环境和社会经济地位。微生物组之间的差异可以通过微生物群落主要基于生态位的组装来解释，这得到了优势测试、β-零偏差和边长丰度分布的支持。大城市中的微生物网络更加脆弱，这可能导致城市化环境中皮肤病的发病率更高。这些结果表明微生物生态理论可以为理解人类微生物组与健康相关的重要特征提供一个框架。
Predominant niche-based process assembly of megacity skin microbiomes results in a relatively fragile microbial network. Given the higher incidence of skin diseases in more urbanized populations and its association with the skin microbiome, we questioned how the skin microbiome differed depending on the degree of urbanization. Skin microbiomes of 231 healthy subjects in five large cities in China varied mainly with environment and socioeconomic status of the cities in question. The differences among microbiomes could be explained by the predominantly niche-based assembly of microbial communities, which was supported by a dominance test, β-null deviation, and edge-length abundance distribution. Networks among microbes in larger cities were more fragile, which may contribute to the higher incidence of skin diseases in more urbanized environments. These results suggest that microbial ecological theory can provide a framework for understanding crucial health-associated features of the human microbiome.
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DOI：
10.1126/science.1224203
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
通讯作者：
Relman DA
影响因子：
4.3
作者：
Faust K;Sathirapongsasuti JF;Izard J;Segata N;Gevers D;Raes J;Huttenhower C
通讯作者：
Huttenhower C
DOI：
10.1073/pnas.1424409112
发表时间：
2015-04-28
影响因子：
11.1
作者：
Bouslimani, Amina;Porto, Carla;Dorrestein, Pieter C.
通讯作者：
Dorrestein, Pieter C.
DOI：
10.1111/j.1096-0031.1992.tb00078.x
发表时间：
1992-12-01
期刊：
CLADISTICS-THE INTERNATIONAL JOURNAL OF THE WILLI HENNIG SOCIETY
影响因子：
--
作者：
FAITH, DP
通讯作者：
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影响因子：
5.9
作者：
FAITH, DP
通讯作者：
FAITH, DP