Relationships between sickle cell trait, malaria, and educational outcomes in Tanzania.
Relationships between sickle cell trait, malaria, and educational outcomes in Tanzania.
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DOI：
10.1186/s12879-017-2644-x
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发表时间：
2017-08-15
影响因子：
3.7
通讯作者：
Mmbando BP
中科院分区：
文献类型：
--
作者：
Croke K;Ishengoma DS;Francis F;Makani J;Kamugisha ML;Lusingu J;Lemnge M;Larreguy H;Fink G;Mmbando BP
镰状细胞性状（SCT）已被证明对疟疾具有保护作用。越来越多的文献表明，接触疟疾会降低受教育程度。本研究评估了坦桑尼亚东北部疟疾、SCT和受教育程度之间的关系和相互作用。从筛查SCT的个体名单中选出767名儿童。2006年1月至2013年12月，社区卫生工作者监测了发热疾病和疟疾发病率。2015年的教育成果提取自科罗格威健康和人口监测系统。主要自变量为疟疾和SCT。分析2006 - 2013年SCT与发热和疟疾发病次数的关系。主要关注的结果是2015年的入学率和教育程度。SCT与学校入学率（调整OR为1.42,95% CI[0.593,3.412]）或最高年级（调整年级差为0.0597,95% CI[- 0.567, 0.686]）无关。SCT与疟疾发病率降低29%相关（校正IRR 0.71, 95% CI[0.526, 0.959]），但与发热发病率无关（校正IRR 0.905, 95% CI[0.709-1.154]）。在SCT个体的亚组分析中，疟疾暴露与入学率下降相关（调整后比值为0.431,95% CI[0.212, 0.877]）。SCT似乎可以降低疟疾的发病率。总的来说，患有SCT的儿童似乎没有接受更多的学校教育；然而，尽管接受了SCT治疗，但感染疟疾的儿童的入学率似乎低于同龄人。
Sickle Cell Trait (SCT) has been shown to be protective against malaria. A growing literature suggests that malaria exposure can reduce educational attainment. This study assessed the relationship and interactions between malaria, SCT and educational attainment in north-eastern Tanzania. Seven hundred sixty seven children were selected from a list of individuals screened for SCT. Febrile illness and malaria incidence were monitored from January 2006 to December 2013 by community health workers. Education outcomes were extracted from the Korogwe Health and Demographic Surveillance system in 2015. The primary independent variables were malaria and SCT. The association between SCT and the number of fever and malaria episodes from 2006 to 2013 was analyzed. Main outcomes of interest were school enrolment and educational attainment in 2015. SCT was not associated with school enrolment (adjusted OR 1.42, 95% CI [0.593,3.412]) or highest grade attained (adjusted grade difference 0.0597, 95% CI [−0.567, 0.686]). SCT was associated with a 29% reduction in malaria incidence (adjusted IRR 0.71, 95% CI [0.526, 0.959]) but not with fever incidence (adjusted IRR 0.905, 95% CI [0.709-1.154]). In subgroup analysis of individuals with SCT, malaria exposure was associated with reduced school enrollment (adjusted OR 0.431, 95% CI [0.212, 0.877]). SCT appears to reduce incidence of malaria. Overall, children with SCT do not appear to attend more years of school; however children who get malaria despite SCT appear to have lower levels of enrolment in education than their peers.
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DOI：
10.1257/app.2.2.46
发表时间：
2010-04
期刊：
American economic journal. Applied economics
影响因子：
--
作者：
Lucas AM
通讯作者：
Lucas AM
影响因子：
6.2
作者：
Bleakley, Hoyt
通讯作者：
Bleakley, Hoyt
影响因子：
6.4
作者：
Williams, TN;Mwangi, TW;Marsh, K
通讯作者：
Marsh, K
影响因子：
3
作者：
Kreuels, Benno;Ehrhardt, Stephan;May, Juergen
通讯作者：
May, Juergen
影响因子：
3
作者：
Mmbando BP;Vestergaard LS;Kitua AY;Lemnge MM;Theander TG;Lusingu JP
通讯作者：
Lusingu JP