Study on the Association of Dietary Fatty Acid Intake and Serum Lipid Profiles With Cognition in Aged Subjects With Type 2 Diabetes Mellitus.
Study on the Association of Dietary Fatty Acid Intake and Serum Lipid Profiles With Cognition in Aged Subjects With Type 2 Diabetes Mellitus.
复制标题
研究饮食脂肪酸摄入量和血清脂质谱与2型糖尿病的老年受试者的认知有关的研究。
DOI：
10.3389/fnagi.2022.846132
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
已有研究报道了老年人群膳食脂肪酸(FA)摄入量和血脂水平与认知功能的相关性。然而，在2型糖尿病(T2 DM)患者中，膳食FA摄入量和血脂水平与认知功能之间的关系的报道很少。在中国老年2型糖尿病人群中进行了一项横断面研究，以探讨膳食脂肪酸摄入量和血脂谱与认知的相关性。共有1,526名中国老年人从社区招募。采集空腹血样进行参数测量。采用食物频率问卷(FFQ)方法进行膳食调查。使用蒙特利尔认知评估(MoCA)测试评估认知能力。比较T2 DM组和对照组膳食FA摄入量和血脂水平。用Logistic回归分析T2 DM患者和正常对照人群FA摄入量和血脂水平与轻度认知损害(MCI)的关系。T2 DM组的血脂水平与对照组比较差异有统计学意义。Logistic回归分析结果显示，血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-c)和膳食n-3多不饱和脂肪酸(PUFAs)摄入量与T2 DM患者发生MCI的风险相关，但在对照组中未观察到相关关系。T2 DM表型可能影响膳食FA摄入量、循环血脂和认知功能之间的关系。需要进行大量前瞻性队列研究，以揭示膳食FA摄入量和血脂水平如何影响老年T2 DM患者认知的潜在机制。
The correlation between dietary fatty acid (FA) intake and serum lipid profile levels with cognition in the aged population has been reported by previous studies. However, the association of dietary FA intake and serum lipid profile levels with cognition in subjects with type 2 diabetes mellitus (T2DM) is seldom reported. A cross-sectional study was conducted to explore the correlation between dietary FA intake and serum lipid profiles with cognition in the aged Chinese population with T2DM. A total of 1,526 aged Chinese subjects were recruited from communities. Fasting blood samples were collected for parameter measurement. The food frequency questionnaire (FFQ) method was applied for a dietary survey. Cognition was assessed using the Montreal Cognitive Assessment (MoCA) test. Dietary FA intake and serum lipid levels were compared between subjects with T2DM and control subjects. A logistic regression analysis was carried out for analyzing the association of FA intake and serum lipid levels with the risk of mild cognitive impairment (MCI) in subjects with T2DM and control subjects. There was a significant difference in the serum lipid level between the T2DM group and the control group. Results of the logistic regression analysis demonstrated the potential associations of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and dietary n-3 polyunsaturated fatty acids (PUFAs) intake with the risk of MCI in subjects with T2DM, but the associations were not observed in control subjects. The T2DM phenotype might affect the relationship between dietary FA intake, circulating lipids, and cognitive performance. Large prospective cohort studies are needed to uncover the underlying mechanism of how dietary FA intake and serum lipid levels affect cognition in aged subjects with T2DM.
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影响因子：
48
作者：
Kellar, Derek;Craft, Suzanne
通讯作者：
Craft, Suzanne
影响因子：
0.7
作者：
Apryatin, S. A.;Sidorova, Yu. S.;Mazo, V. K.
通讯作者：
Mazo, V. K.
蒙特利尔认知评估检测中国老年人认知障碍：一项基于人群的研究
影响因子：
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作者：
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通讯作者：
Jia, Jianping
DOI：
10.3233/jad-170440
发表时间：
2017
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Karki R;Kodamullil AT;Hofmann-Apitius M
通讯作者：
Hofmann-Apitius M
影响因子：
6.1
作者：
Li R;Wang TJ;Lyu PY;Liu Y;Chen WH;Fan MY;Xu J
通讯作者：
Xu J