Relationships between Lymph Node Metastasis and Expression of CD31, D2-40, and Vascular Endothelial Growth Factors A and C in Papillary Thyroid Cancer.
Relationships between Lymph Node Metastasis and Expression of CD31, D2-40, and Vascular Endothelial Growth Factors A and C in Papillary Thyroid Cancer.
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DOI：
10.3342/ceo.2012.5.3.150
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发表时间：
2012-09
影响因子：
3
通讯作者：
Kim WS
中科院分区：
文献类型：
--
作者：
Lee SH;Lee SJ;Jin SM;Lee NH;Kim DH;Chae SW;Sohn JH;Kim WS
探讨甲状腺乳头状癌(PTC)中CD31、D2-40和血管内皮生长因子(VEGF)-A、-C的表达与淋巴结转移的关系。石蜡包埋甲状腺组织72例，其中甲状腺结节增生症(TNH)25例，PTC非LNM组24例，PTC伴LNM组23例。三名对患者临床信息视而不见的病理学家对免疫组织化学染色结果进行了评估。按高(染色细胞的25%)或低(0~25%)进行评分。与TNH组(分别为91.3%、79.2%、4.0%)相比，PTC组无论LNM大小，其VEGF-A的表达水平均显著升高(P<0.05)。PTC合并LNM组的VEGF-C表达明显高于其他两组(P<；0.05)。CD31的微血管密度(MVD)评分在三组间无差异。D2-40淋巴管密度(LVD)评分在PTC伴LNM组显著高于其他组(P<；0.05)。VEGF-C和D2-40在伴有LNM的PTC患者中的表达高于无LNM的PTC患者和TNH患者。应用D2-40分析血管内皮生长因子-C水平和LVD有助于PTC的诊断和评估PTC患者的LNM潜能。
To investigate the relationships between lymph node metastasis (LNM) and expression of CD31, D2-40 and vascular endothelial growth factors (VEGF)-A and -C in patients with papillary thyroid cancer (PTC). Paraffin-embedded thyroid tissues of 72 patients were evaluated, which included 25 patients with thyroid nodular hyperplasia (TNH), 24 PTC patients without LNM, and 23 PTC patients with LNM. Three pathologists, who were blinded to the patient's clinical information, assessed the immunohistochemical staining results. The amount of expression was scored as high (>25% of cells stained) or low (0-25%). A higher level of VEGF-A expression was observed in the PTC groups regardless of LNM when compared to the group with TNH (91.3%, 79.2%, 4.0%, respectively). VEGF-C expression in the PTC with LNM group was significantly higher than the other two groups (P<0.05). No difference in microvessel density (MVD) scores was observed using CD31 among the three groups. The lymphatic vessel density (LVD) score using D2-40 was significantly higher in patients having PTC with LNM than the other groups (P<0.05). VEGF-C and D2-40 were more highly expressed in patients having PTC with LNM than in patients having PTC without LNM or in those having TNH. Analysis of VEGF-C level and LVD using D2-40 may be helpful in the diagnosis of PTC and the evaluation of LNM potential in patients with PTC.
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影响因子：
3.6
作者：
HERRMANN, G;SCHUMMDRAEGER, PM;HUBNER, K
通讯作者：
HUBNER, K
影响因子：
3.4
作者：
Sahni, D;Robson, A;Russell-Jones, R
通讯作者：
Russell-Jones, R
影响因子：
6
作者：
Bunone, G;Vigneri, P;Bongarzone, I
通讯作者：
Bongarzone, I
影响因子：
56.9
作者：
Padera, TP;Kadambi, A;Jain, RK
通讯作者：
Jain, RK
影响因子：
6
作者：
Lohela, Marja;Helotera, Hanna;Alitalo, Kari
通讯作者：
Alitalo, Kari