Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder.
Inter-individual heterogeneity of functional brain networks in children with autism spectrum disorder.
复制标题
自闭症谱系障碍儿童大脑功能网络的个体间异质性
DOI：
10.1186/s13229-022-00535-0
复制
发表时间：
2022-12-26
期刊：
影响因子：
6.2
通讯作者：
中科院分区：
文献类型：
--
作者：
孤独症谱系障碍（ASD）是一种临床异质性很大的神经发育障碍。本研究旨在从个体间脑功能网络的异质性探讨ASD的异质性。在这项研究中，105名ASD儿童和102名人口统计学匹配的典型对照（TC）儿童使用了来自自闭症脑成像数据交换数据库的静息状态功能磁共振成像数据。首先获得ASD和TC组的功能连接（FC）网络，然后计算每个ASD个体的TC组功能连接（IDFC）个体间偏差。采用k-means聚类算法根据IDFC模式获得ASD亚型。进一步从脑区、网络和全脑水平比较ASD亚型和TC组的FC模式。还使用支持向量回归模型分析了ASD亚型的IDFC与ASD临床症状严重程度之间的关系。根据IDFC模式确定了两种ASD亚型。与TC组相比，ASD亚型1组表现为低连接模式，ASD亚型2组表现为高连接模式。ASD亚型1和亚型2的IDFC被发现分别预测ASD中社交障碍的严重程度以及限制和重复行为的严重程度。这项研究只选择了男孩，这限制了研究性别和发育对ASD异质性影响的能力。这些结果提示ASD中存在具有不同FC模式的亚型，并为ASD临床表现的复杂病理生理机制提供了见解。在线版本包含补充材料，可通过10.1186/s13229-022-00535-0获得。
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable clinical heterogeneity. This study aimed to explore the heterogeneity of ASD based on inter-individual heterogeneity of functional brain networks. Resting-state functional magnetic resonance imaging data from the Autism Brain Imaging Data Exchange database were used in this study for 105 children with ASD and 102 demographically matched typical controls (TC) children. Functional connectivity (FC) networks were first obtained for ASD and TC groups, and inter-individual deviation of functional connectivity (IDFC) from the TC group was then calculated for each individual with ASD. A k-means clustering algorithm was used to obtain ASD subtypes based on IDFC patterns. The FC patterns were further compared between ASD subtypes and the TC group from the brain region, network, and whole-brain levels. The relationship between IDFC and the severity of clinical symptoms of ASD for ASD subtypes was also analyzed using a support vector regression model. Two ASD subtypes were identified based on the IDFC patterns. Compared with the TC group, the ASD subtype 1 group exhibited a hypoconnectivity pattern and the ASD subtype 2 group exhibited a hyperconnectivity pattern. IDFC for ASD subtype 1 and subtype 2 was found to predict the severity of social communication impairments and the severity of restricted and repetitive behaviors in ASD, respectively. Only male children were selected for this study, which limits the ability to study the effects of gender and development on ASD heterogeneity. These results suggest the existence of subtypes with different FC patterns in ASD and provide insight into the complex pathophysiological mechanism of clinical manifestations of ASD. The online version contains supplementary material available at 10.1186/s13229-022-00535-0.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.8
作者：
Fan YS;Li L;Peng Y;Li H;Guo J;Li M;Yang S;Yao M;Zhao J;Liu H;Liao W;Guo X;Han S;Cui Q;Duan X;Xu Y;Zhang Y;Chen H
通讯作者：
Chen H
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
影响因子：
14.5
作者：
Just, MA;Cherkassky, VL;Minshew, NJ
通讯作者：
Minshew, NJ
影响因子：
9.9
作者：
Aylward, EH;Minshew, NJ;Singh, N
通讯作者：
Singh, N