Bitter Taste Receptors (T2Rs) are Sentinels that Coordinate Metabolic and Immunological Defense Responses.
Bitter Taste Receptors (T2Rs) are Sentinels that Coordinate Metabolic and Immunological Defense Responses.
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DOI:
10.1016/j.cophys.2021.01.006
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发表时间:
2021-04
影响因子:
2.5
通讯作者:
Breslin PAS
中科院分区:
文献类型:
--
作者:
Harmon CP;Deng D;Breslin PAS
In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate endocrine, behavioral, and immunological responses. T2R agonists include indicators of incoming threats to metabolic homeostasis, pathogens, and irritants. This review will provide an overview of T2R-regulated processes throughout the body that function defensively. We propose a broader definition of T2Rs as chemosensory sentinels that monitor toxic, metabolic, and infectious threats and initiate defensive responses.
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DOI:
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期刊:
Brain, behavior, and immunity
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