Advanced Role of Hippo Signaling in Endometrial Fibrosis: Implications for Intrauterine Adhesion.
Advanced Role of Hippo Signaling in Endometrial Fibrosis: Implications for Intrauterine Adhesion.
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Hippo 信号传导在子宫内膜纤维化中的高级作用：对宫内粘连的影响
DOI：
10.4103/0366-6999.218013
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发表时间：
2017-11-20
影响因子：
6.1
通讯作者：
Zhang SY
中科院分区：
文献类型：
--
作者：
Zhu HY;Ge TX;Pan YB;Zhang SY
目的：宫内粘连（IUA）是导致女性不孕、月经不规律和反复流产的主要健康问题。不幸的是，IUA的治疗是有限的，目前还没有有效的策略来预防IUA复发。在这篇综述中，我们介绍了Hippo信号通路在正常子宫内膜和IUA中的作用，并描述了Hippo通路与Wnt和转化生长因子-&bgr；（TGF-&bgr;）信号通路形成调控纤维化发展的复杂网络。数据来源：从PubMed数据库中收集2017年7月之前发表的英文原创研究文章。研究选择：使用检索词“子宫内膜纤维化或纤维化和或或宫内粘连或Asherman综合征或IUA”、“Hippo和或Hippo/TAZ”、“TGF-&bgr；和“Wnt”。综合分析纳入相关原创研究文章。结果：子宫内膜纤维化被认为是IUA发展的关键病理事件，其特征是上皮/成纤维细胞向肌成纤维细胞过渡。肌成纤维细胞在纤维瘢痕形成的发病机制中起着至关重要的作用，肌成纤维细胞分化可通过多种信号通路触发。Hippo信号是上皮/成纤维细胞-肌成纤维细胞转化和&agr；-平滑肌肌动蛋白，在子宫内膜中表现出特定的时空表达。结论：Hippo信号在纤维性疾病中起关键作用，参与与Wnt、TGF-&bgr的交叉对话；信号。我们的发现不仅有助于了解子宫内膜纤维化的发病机制，而且可以为开发用于IUA治疗和预防的特异性分子抑制剂提供有用的资源。
Objective: Intrauterine adhesion (IUA) is a major health problem that causes infertility, menstrual irregularities, and recurrent pregnancy losses in women. Unfortunately, treatments for IUA are limited, and there are currently no effective strategies for preventing IUA recurrence. In this review, we introduced the role of Hippo signaling in the normal endometrium and IUA and described the mechanisms by which the Hippo pathway integrates with the Wnt and transforming growth factor-&bgr; (TGF-&bgr;) signaling pathways to form an intricate network governing the development of fibrosis. Data Sources: Original research articles in English that were published until July 2017 were collected from the PubMed database. Study Selection: Literature search was conducted using the search terms “endometrial fibrosis OR fibrosis AND or OR intrauterine adhesion OR Asherman syndrome OR IUA,” “Hippo AND or OR Hippo/TAZ,” “TGF-&bgr;,” and “Wnt.” Related original research articles were included in the comprehensive analysis. Results: Endometrial fibrosis is recognized as a key pathological event in the development of IUA, which is characterized by epithelial/fibroblast–myofibroblast transition. Myofibroblasts play crucial roles in the pathogenesis of fibrous scarring, and myofibroblast differentiation can be triggered by multiple signaling pathways. Hippo signaling is a critical regulator of the epithelial/fibroblast–myofibroblast transition and &agr;-smooth muscle actin, which exhibits a specific spatiotemporal expression in the endometrium. Conclusions: Hippo signaling plays a critical role in fibrous diseases and participates in cross talks with Wnt and TGF-&bgr; signaling. Our findings not only contributed to knowledge on the pathogenesis of endometrial fibrosis, but can also serve as a useful resource for developing specific molecular inhibitors for IUA treatment and prevention.
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DOI：
10.1126/science.1199010
发表时间：
2011-04-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Heallen T;Zhang M;Wang J;Bonilla-Claudio M;Klysik E;Johnson RL;Martin JF
通讯作者：
Martin JF
影响因子：
3.8
作者：
Chen, Hengxi;Song, Yong;Huang, Wei
通讯作者：
Huang, Wei
影响因子：
4
作者：
Gumbiner, Barry M.;Kim, Nam-Gyun
通讯作者：
Kim, Nam-Gyun
影响因子：
5.5
作者：
Lange, Alexander W.;Sridharan, Anusha;Whitsett, Jeffrey A.
通讯作者：
Whitsett, Jeffrey A.
影响因子：
64.5
作者：
Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia