Continuous Flow Microfluidic Bioparticle Concentrator.
Continuous Flow Microfluidic Bioparticle Concentrator.
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DOI：
10.1038/srep11300
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发表时间：
2015-06-10
影响因子：
4.6
通讯作者：
Toner M
中科院分区：
文献类型：
--
作者：
Martel JM;Smith KC;Dlamini M;Pletcher K;Yang J;Karabacak M;Haber DA;Kapur R;Toner M
Innovative microfluidic technology has enabled massively parallelized and extremely efficient biological and clinical assays. Many biological applications developed and executed with traditional bulk processing techniques have been translated and streamlined through microfluidic processing with the notable exception of sample volume reduction or centrifugation, one of the most widely utilized processes in the biological sciences. We utilize the high-speed phenomenon known as inertial focusing combined with hydraulic resistance controlled multiplexed micro-siphoning allowing for the continuous concentration of suspended cells into pre-determined volumes up to more than 400 times smaller than the input with a yield routinely above 95% at a throughput of 240 ml/hour. Highlighted applications are presented for how the technology can be successfully used for live animal imaging studies, in a system to increase the efficient use of small clinical samples, and finally, as a means of macro-to-micro interfacing allowing large samples to be directly coupled to a variety of powerful microfluidic technologies.
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影响因子：
14.8
作者：
通讯作者：
--
影响因子：
16.6
作者：
Lim, Eugene J.;Ober, Thomas J.;Edd, Jon F.;Desai, Salil P.;Neal, Douglas;Bong, Ki Wan;Doyle, Patrick S.;McKinley, Gareth H.;Toner, Mehmet
通讯作者：
Toner, Mehmet
影响因子：
56.9
作者：
Huang, LR;Cox, EC;Sturm, JC
通讯作者：
Sturm, JC
影响因子：
7.4
作者：
Di Carlo, Dino;Edd, Jon F.;Toner, Mehmet
通讯作者：
Toner, Mehmet
DOI：
10.1073/pnas.0704958104
发表时间：
2007-11-27
影响因子：
11.1
作者：
Di Carlo, Dino;Irimia, Daniel;Toner, Mehmet
通讯作者：
Toner, Mehmet