Two-year neurocognitive responses to first occupational lead exposure.
Two-year neurocognitive responses to first occupational lead exposure.
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DOI：
10.5271/sjweh.3940
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发表时间：
2021-04-01
期刊：
影响因子：
--
通讯作者：
Zhang ZY
中科院分区：
文献类型：
--
作者：
Yu YL;Thijs L;Saenen N;Melgarejo JD;Wei DM;Yang WY;Yu CG;Roels HA;Nawrot TS;Maestre GE;Staessen JA;Zhang ZY
铅暴露会导致儿童神经认知功能障碍，但在目前的职业暴露水平下，铅暴露与成人神经认知的关系尚不确定，主要是由于缺乏纵向研究。在促进回收铅的健康研究（NCT 02243904）中，我们评估了在铅回收厂新雇用的没有已知职业暴露的工人的神经认知功能的两年反应。工人在基线和年度随访时完成数字符号测试（DST）和Stroop测试（ST）。通过电感耦合等离子体质谱法（检测限0.5 µg/dL）测量血铅（BL）。统计方法包括多变量调整混合模型，参与者建模为随机效应。对260名参与者进行了DST（11.9%女性; 46.9%/45.0%白人/西班牙裔;平均年龄29.4岁），对168名参与者进行了ST。DST和ST队列中基线BL的几何平均值分别为3.97和4.13 µg/dL，末次随访至基线BL比值的几何平均值分别为3.30和3.44。在部分校正的模型中，BL比率加倍与潜伏时间（DST）增加0.66% [95%置信区间（CI）0.03-1.30%; P=0.040]和推断效应（ST）降低0.35%（95% CI -1.63-1.63%; P=0.59）相关。在完全校正的模型中，DST和ST试验结果的变化与血铅变化的相关性均未达到统计学显著性（P≥0.12）。超过3倍的血铅增加超过两年的职业暴露与认知能力的相关下降无关。
Lead exposure causes neurocognitive dysfunction in children, but its association with neurocognition in adults at current occupational exposure levels is uncertain mainly due to the lack of longitudinal studies. In the Study for Promotion of Health in Recycling Lead (NCT02243904), we assessed the two-year responses of neurocognitive function among workers without previous known occupational exposure newly hired at lead recycling plants. Workers completed the digit-symbol test (DST) and Stroop test (ST) at baseline and annual follow-up visits. Blood lead (BL) was measured by inductively coupled plasma mass spectrometry (detection limit 0.5 µg/dL). Statistical methods included multivariable-adjusted mixed models with participants modelled as random effect. DST was administered to 260 participants (11.9% women; 46.9%/45.0% whites/Hispanics; mean age 29.4 years) and ST to 168 participants. Geometric means were 3.97 and 4.13 µg/dL for baseline BL, and 3.30 and 3.44 for the last-follow-up-to-baseline BL ratio in DST and ST cohorts, respectively. In partially adjusted models, a doubling of the BL ratio was associated with a 0.66% [95% confidence interval (CI) 0.03–1.30%; P=0.040] increase in latency time (DST) and a 0.35% (95% CI -1.63–1.63%; P=0.59) decrease in the inference effect (ST). In fully adjusted models, none of the associations of the changes in the DST and ST test results with the blood lead changes reached statistical significance (P≥0.12). An over 3-fold increase in blood lead over two years of occupational exposure was not associated with a relevant decline in cognitive performance.
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影响因子：
8.3
作者：
Hara, Azusa;Thijs, Lutgarde;Staessen, Jan A.
通讯作者：
Staessen, Jan A.
影响因子：
8.3
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Weisskopf, Marc G.
影响因子：
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120.7
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MATTE, TD
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168.9
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通讯作者：
Ezzati, Majid