Low educational level of head of household, as a proxy for poverty, is associated with severe anaemia among children with sickle cell disease living in a low-resource setting: evidence from the SPRING trial.
Low educational level of head of household, as a proxy for poverty, is associated with severe anaemia among children with sickle cell disease living in a low-resource setting: evidence from the SPRING trial.
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DOI：
10.1111/bjh.16746
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发表时间：
2020-09
影响因子：
6.5
通讯作者：
Galadanci NA
中科院分区：
文献类型：
--
作者：
Bello-Manga H;Galadanci AA;Abdullahi S;Ali S;Jibir B;Gambo S;Haliru L;Jordan LC;Aliyu MH;Rodeghier M;Kassim AA;DeBaun MR;Galadanci NA
严重贫血，定义为血红蛋白水平<6.0 g/dL，是生活在资源有限环境中的镰状细胞病患者死亡的独立风险因素。我们对941名镰状细胞性贫血儿童进行了一项横断面研究;定义为表型HbSS或HbSβ0地中海贫血，年龄为5至12岁，筛选入组尼日利亚的一项大型一级卒中预防试验（SPRING; NCT 02560935）。这项研究的主要目的是确定严重贫血的患病率和危险因素。我们发现严重贫血存在于3.9%（37/941）的SPRING研究参与者中。严重贫血与户主的教育程度较低（P=0.003）和家庭中每个房间的儿童数量较多（P=0.004）显著相关。体重指数与严重贫血无关。尼日利亚镰状细胞性贫血儿童严重贫血的病因可能是多因素的，个人疾病严重程度与其他与贫困有关的社会经济因素之间存在相互作用。
Severe anemia, defined as hemoglobin level <6.0 g/dL, is an independent risk factor for death in individuals with sickle cell disease living in resource-limited settings. We conducted a cross-sectional study of 941 children with sickle cell anemia; defined as phenotype HbSS or HbSβ0 thalassemia, aged 5 to 12 years screened for enrollment into a large primary stroke prevention trial in Nigeria (SPRING; NCT02560935). The main aim of the study was to determine the prevalence and risk factors for severe anemia. We found severe anemia to be present in 3.9% (37 of 941) of the SPRING study participants. Severe anemia was significantly associated with a lower educational status of head of household (P=0.003) and a greater number of children per room in the household (P=0.004). Body mass index was not associated with severe anemia. The etiology of severe anemia in children living with sickle cell anemia in Nigeria is likely to be multifactorial with an interplay between an individual’s disease severity and other socio-economic factors related to poverty.
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