CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone.
CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone.
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DOI：
10.1371/journal.pone.0029688
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Corvera S
中科院分区：
文献类型：
--
作者：
Young JL;Mora A;Cerny A;Czech MP;Woda B;Kurt-Jones EA;Finberg RW;Corvera S
Toll样受体是先天免疫系统中最保守的成分之一，表明存在微生物来源的分子。已有研究表明，通过TLR4传递的信号需要CD14识别细菌脂多糖(LPS)，可能会产生低度炎症，从而影响胰岛素敏感性和葡萄糖代谢。为了检测部分先天免疫信号中断对血糖稳态的长期影响，我们分析了CD14缺陷基因敲除小鼠在6个月或12个月大时回交到易患糖尿病的C57BL6背景中。与野生型对照相比，CD14-KO小鼠，无论是喂食正常饲料还是高脂饮食，都表现出明显的葡萄糖耐量异常。他们还表现出去甲肾上腺素尿排泄增加和肾上腺髓质体积增加，以及去甲肾上腺素对胰岛素诱导的低血糖的分泌反应增强。这些结果指出了先天免疫系统和交感肾上腺系统之间以前未被认识到的串扰，这对血糖稳态产生了重大的长期影响。
The toll-like receptors comprise one of the most conserved components of the innate immune system, signaling the presence of molecules of microbial origin. It has been proposed that signaling through TLR4, which requires CD14 to recognize bacterial lipopolysaccharide (LPS), may generate low-grade inflammation and thereby affect insulin sensitivity and glucose metabolism. To examine the long-term influence of partial innate immune signaling disruption on glucose homeostasis, we analyzed knockout mice deficient in CD14 backcrossed into the diabetes-prone C57BL6 background at 6 or 12 months of age. CD14-ko mice, fed either normal or high-fat diets, displayed significant glucose intolerance compared to wild type controls. They also displayed elevated norepinephrine urinary excretion and increased adrenal medullary volume, as well as an enhanced norepinephrine secretory response to insulin-induced hypoglycemia. These results point out a previously unappreciated crosstalk between innate immune- and sympathoadrenal- systems, which exerts a major long-term effect on glucose homeostasis.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
16.2
作者：
Fröhlich, M;Imhof, A;Koenig, W
通讯作者：
Koenig, W
DOI：
10.1073/pnas.0407550101
发表时间：
2004-11-23
影响因子：
11.1
作者：
Bornstein, SR;Zacharowski, P;Zacharowski, K
通讯作者：
Zacharowski, K
影响因子：
24.5
作者：
Cani PD;Possemiers S;Van de Wiele T;Guiot Y;Everard A;Rottier O;Geurts L;Naslain D;Neyrinck A;Lambert DM;Muccioli GG;Delzenne NM
通讯作者：
Delzenne NM
影响因子：
4.7
作者：
Gonzalez, A. Soto;Guerrero, D. Bellido;Vidal, O.
通讯作者：
Vidal, O.