High burden of tuberculosis infection and disease among people receiving medication-assisted treatment for substance use disorder in Tanzania.
High burden of tuberculosis infection and disease among people receiving medication-assisted treatment for substance use disorder in Tanzania.
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DOI：
10.1371/journal.pone.0250038
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Reither K
中科院分区：
文献类型：
--
作者：
Minja LT;Hella J;Mbwambo J;Nyandindi C;Omary US;Levira F;Mpagama S;Shimwela M;Okuma J;Gagneux S;Bruce RD;Reither K
确定坦桑尼亚达累斯萨拉姆药物辅助治疗（MAT）诊所的药物使用者（PWUD）中结核病（TB）和感染的患病率以及突发TB疾病。在这项前瞻性队列研究中，从2016年11月至2017年2月共招募了901名知情同意的参与者，并通过Android平板电脑上的开放数据包应用程序向他们进行了结构化问卷调查。22个月后，我们再次访问了MAT诊所，并审查了901名登记参与者的医疗记录中的823份，以寻找有关结核病诊断和治疗的文件。审查的医疗记录包括那些在登记时无症状，未接受结核病治疗，未接受结核病预防治疗的参与者和那些有记录的结核菌素皮肤试验（TST）结果的参与者。在入组后22个月审查的823份病历中，42份有被诊断患有结核病并开始结核病治疗的记录。这相当于结核病发病率为2，925.2例/100，000人年，总随访时间为1，440人年。在入学时，结核病和结核感染的流行率分别为2.6%和54%，男女艾滋病毒流行率分别为44%和16%。在MAT诊所就诊的PWUD承担着极高的结核病和艾滋病毒负担，并且已知在许多国家推动了结核病的流行。我们报告的结核病发病率是坦桑尼亚一般发病率（每10万人237例）的12倍，这进一步强调了这一群体应优先接受结核病筛查、检测和治疗。还应制定针对性别的办法，因为女性残疾人比男性残疾人更容易感染艾滋病毒和结核病。
To determine the prevalence of tuberculosis (TB) disease and infection as well as incident TB disease among people who use drugs (PWUD) attending Medication Assisted Treatment (MAT) clinics in Dar-es-Salaam, Tanzania. In this prospective cohort study, a total of 901 consenting participants were enrolled from November 2016 to February 2017 and a structured questionnaire administered to them through the open data kit application on android tablets. Twenty-two months later, we revisited the MAT clinics and reviewed 823 of the 901 enrolled participant’s medical records in search for documentation on TB disease diagnosis and treatment. Medical records reviewed included those of participants whom at enrolment were asymptomatic, not on TB disease treatment, not on TB preventive therapy and those who had a documented tuberculin skin test (TST) result. Of the 823 medical records reviewed 22 months after enrolment, 42 had documentation of being diagnosed with TB disease and initiated on TB treatment. This is equivalent to a TB disease incidence rate of 2,925.2 patients per 100,000 person years with a total follow up time of 1,440 person-years. At enrolment the prevalence of TB disease and TB infection was 2.6% and 54% respectively and the HIV prevalence was 44% and 16% among females and males respectively. PWUD attending MAT clinics bear an extremely high burden of TB and HIV and are known to have driven TB epidemics in a number of countries. Our reported TB disease incidence is 12 times that of the general Tanzanian incidence of 237 per 100,000 further emphasizing that this group should be prioritized for TB screening, testing and treatment. Gender specific approaches should also be developed as female PWUDs are markedly more affected with HIV and TB disease than male PWUDs.
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DOI：
10.1086/594126
发表时间：
2009-01-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
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3.7
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DOI：
10.1001/archfami.4.6.541
发表时间：
1995-06-01
期刊：
Archives of family medicine
影响因子：
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DOI：
10.1093/cid/ciaa1402
发表时间：
2021-08-02
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
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作者：
Frascella B;Richards AS;Sossen B;Emery JC;Odone A;Law I;Onozaki I;Esmail H;Houben RMGJ
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Houben RMGJ