Brown adipose tissue activation is inversely related to central obesity and metabolic parameters in adult human.
Brown adipose tissue activation is inversely related to central obesity and metabolic parameters in adult human.
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棕色脂肪组织的激活与成人中心性肥胖和代谢参数呈负相关
DOI：
10.1371/journal.pone.0123795
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Wang Q;Zhang M;Xu M;Gu W;Xi Y;Qi L;Li B;Wang W
背景近年来的研究表明，成人体内存在活性棕色脂肪组织(BAT)，这可能是影响肥胖的重要因素。然而，在大量基于人群的研究中，关于BAT与中心性肥胖和代谢特征之间关系的支持证据很少。方法/主要研究结果我们对4011名(男2688名，女1323名)18-年龄的无肿瘤成人进行了BAT活动、内脏/皮下脂肪面积(VFA/SFA)、腰围(WC)和代谢参数的研究。我们发现，在我们的研究参与者中，BAT的患病率约为2.7%，性别差异显著(女性为5.5%，男性为1.3%；p<；0.0001)。BAT检测在低温时升高，在老年组下降。与BAT阴性组相比，BAT阳性组的体重指数(P<；0.0001)、饱和脂肪酸(P<；0.01)、挥发性脂肪酸(P<；0.0001)、WC(P<；0.0001)、空腹血糖和甘油三酯水平(P<；0.01)降低，高密度脂蛋白(P<；0.0001)升高。Logistic回归分析显示，调整协变量(包括年龄、性别、体重指数、挥发性脂肪酸、饱和脂肪酸和腰围)、年龄和体重指数后，男性的年龄和体重指数分别为0.92[95%CI，0.88~0.96]和0.84[95%CI，0.75~0.96]，女性的年龄和挥发性脂肪酸分别为0.87[95%CI，0.83~0.91]和0.98[95%CI，0.97~0.99]，P<；0.008。结论/意义我们的数据表明，活跃的BAT数量减少可能与内脏脂肪含量的积累和不利的代谢结果有关。
Background Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in affecting obesity. However, the supporting evidence on the relationship between BAT and central obesity and metabolic profile in large population based studies is sparse. Methodology/Principal Findings We studied 4011 (2688 males and 1323 females) tumor-free Chinese adults aged 18-89 for BAT activities, visceral/subcutaneous fat areas (VFA/SFA), waist circumferences (WC) and metabolic parameters. We found that the prevalence of BAT was around 2.7% in our study participants, with a significant sexual difference (5.5% in the females vs. 1.3% in the males; p<0.0001). BAT detection was increased in low temperature and declined in elderly subjects. The BAT positive subjects had lower BMI (P<0.0001), less SFA (P<0.01), VFA (P<0.0001), WC (P<0.0001), lower fasting glucose and triglyceride levels (both P<0.01) and increased HDL cholesterol concentrations (P<0.0001), compared with the BAT negative subjects. Robust logistic regression revealed that after adjustment for covariates (including age, sex, BMI, VFA, SFA and WC), age and BMI in the males (0.92 [95%CI, 0.88-0.96] and 0.84 [95% CI, 0.75-0.96], both P ≤0.008) while age and VFA in the females (0.87 [95%CI, 0.83-0.91] and 0.98 [95%CI, 0.97-0.99], respectively, P<0.05) were independently associated with detectable BAT. Conclusions/Significance Our data suggest that decreased amount of active BAT might be associated with accumulation of visceral fat content and unfavorable metabolic outcomes.
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影响因子：
105.7
作者：
LARSSON, B;SVARDSUDD, K;TIBBLIN, G
通讯作者：
TIBBLIN, G
影响因子：
4.8
作者：
Hamann, A;Flier, JS;Lowell, BB
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Cummings, SR
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16.2
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Newell-Morris, L
影响因子：
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作者：
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通讯作者：
Bray, George A.