Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice.
Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice.
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老年糖尿病小鼠心脏 H2S 生成量减少。
DOI：
10.1155/2015/758358
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发表时间：
2015
影响因子：
--
通讯作者：
Zhu YC
中科院分区：
文献类型：
--
作者：
Jin S;Pu SX;Hou CL;Ma FF;Li N;Li XH;Tan B;Tao BB;Wang MJ;Zhu YC
目标。研究衰老糖尿病小鼠心脏中硫化氢（H2S）的产生是否发生变化。结果与仅喂食自来水的小鼠相比，喂食30%果糖溶液15个月的小鼠表现出严重糖尿病表型的典型特征，包括心脏肥大、纤维化和功能障碍。与对照组相比，这些小鼠血浆、心脏组织和尿液中的H2S水平显著降低。在果糖喂养的小鼠心脏中，H2S生成酶、胱硫醚γ-裂解酶和3-巯基丙酮酸硫转移酶的表达显著降低，而胱硫醚-β-合成酶水平显著升高。结论我们的研究结果表明，这种老年糖尿病小鼠模型发展为糖尿病心肌病，并且由于三种H2S产生酶的改变，糖尿病心脏中的H2S水平降低，这可能参与糖尿病心肌病的发病机制。
Aims. To examine whether hydrogen sulfide (H2S) generation changed in ageing diabetic mouse hearts. Results. Compared to mice that were fed tap water only, mice that were fed 30% fructose solution for 15 months exhibited typical characteristics of a severe diabetic phenotype with cardiac hypertrophy, fibrosis, and dysfunction. H2S levels in plasma, heart tissues, and urine were significantly reduced in these mice as compared to those in controls. The expression of the H2S-generating enzymes, cystathionine γ-lyase and 3-mercaptopyruvate sulfurtransferase, was significantly decreased in the hearts of fructose-fed mice, whereas cystathionine-β-synthase levels were significantly increased. Conclusion. Our results suggest that this ageing diabetic mouse model developed diabetic cardiomyopathy and that H2S levels were reduced in the diabetic heart due to alterations in three H2S-producing enzymes, which may be involved in the pathogenesis of diabetic cardiomyopathy.
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影响因子：
4.8
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