Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients.
Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients.
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DOI：
10.2337/dc12-1652
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发表时间：
2013-06
期刊：
影响因子：
16.2
通讯作者：
Avignon A
中科院分区：
文献类型：
--
作者：
Hokayem M;Blond E;Vidal H;Lambert K;Meugnier E;Feillet-Coudray C;Coudray C;Pesenti S;Luyton C;Lambert-Porcheron S;Sauvinet V;Fedou C;Brun JF;Rieusset J;Bisbal C;Sultan A;Mercier J;Goudable J;Dupuy AM;Cristol JP;Laville M;Avignon A
目的：评估营养量葡萄多酚(PPS)对抗高果糖饮食代谢改变的临床疗效，包括氧化应激和胰岛素抵抗(IR)，在具有高代谢风险的健康志愿者中。38名2型糖尿病患者的健康超重/肥胖一级亲属(18名男性和20名女性)在葡萄PP(2g/d)和安慰剂(PCB)组之间进行了随机双盲对照试验。受试者在基线以及补充8周和9周后进行调查，在最后6天，他们都接受了3g/kg脱脂质量/天的果糖。主要终点是葡萄PPS对果糖诱导的IR的保护作用。在PCB组，果糖导致1)肝脏胰岛素敏感指数下降20%(P<；0.05)和葡萄糖输注率下降11%(P<；0.05)，2)全身(尿中F2-异前列腺素)和肌肉(硫代巴比妥酸反应物质和蛋白质羰化)氧化应激增加(P<；0.05)，以及3)线粒体基因下调和线粒体呼吸减少(P<；0.05)。果糖的所有有害作用都被添加葡萄PP完全钝化了。抗氧化防御、炎症标志物和主要脂肪因子既不受果糖影响，也不受葡萄PPS影响。营养剂量的葡萄PPS的天然混合物有效地防止果糖诱导的氧化应激和IR。目前全球食品和营养行业对葡萄PP成分和产品的兴趣很可能使它们成为预防性营养的垫脚石。
To assess the clinical efficacy of nutritional amounts of grape polyphenols (PPs) in counteracting the metabolic alterations of high-fructose diet, including oxidative stress and insulin resistance (IR), in healthy volunteers with high metabolic risk. Thirty-eight healthy overweight/obese first-degree relatives of type 2 diabetic patients (18 men and 20 women) were randomized in a double-blind controlled trial between a grape PP (2 g/day) and a placebo (PCB) group. Subjects were investigated at baseline and after 8 and 9 weeks of supplementation, the last 6 days of which they all received 3 g/kg fat-free mass/day of fructose. The primary end point was the protective effect of grape PPs on fructose-induced IR. In the PCB group, fructose induced 1) a 20% decrease in hepatic insulin sensitivity index (P < 0.05) and an 11% decrease in glucose infusion rate (P < 0.05) as evaluated during a two-step hyperinsulinemic-euglycemic clamp, 2) an increase in systemic (urinary F2-isoprostanes) and muscle (thiobarbituric acid–reactive substances and protein carbonylation) oxidative stress (P < 0.05), and 3) a downregulation of mitochondrial genes and decreased mitochondrial respiration (P < 0.05). All the deleterious effects of fructose were fully blunted by grape PP supplementation. Antioxidative defenses, inflammatory markers, and main adipokines were affected neither by fructose nor by grape PPs. A natural mixture of grape PPs at nutritional doses efficiently prevents fructose-induced oxidative stress and IR. The current interest in grape PP ingredients and products by the global food and nutrition industries could well make them a stepping-stone of preventive nutrition.
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影响因子：
5.6
作者：
Terra, Ximena;Montagut, Gemma;Blay, Mayte
通讯作者：
Blay, Mayte
DOI：
10.1073/pnas.1032913100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Patti, ME;Butte, AJ;Mandarino, LJ
通讯作者：
Mandarino, LJ
影响因子：
15.9
作者：
Bonnard, Charlotte;Durand, Annie;Rieusset, Jennifer
通讯作者：
Rieusset, Jennifer
DOI：
10.1016/j.jchromb.2008.07.037
发表时间：
2008-09-01
影响因子：
3
作者：
Mas, Emilie;Michel, Francoise;Durand, Thierry
通讯作者：
Durand, Thierry
影响因子：
9.8
作者：
Cordain, L;Melby, CL;Hill, JO
通讯作者：
Hill, JO