Preference for gel over suppository as delivery vehicle for a rectal microbicide: results of a randomised, crossover acceptability trial among men who have sex with men.
Preference for gel over suppository as delivery vehicle for a rectal microbicide: results of a randomised, crossover acceptability trial among men who have sex with men.
复制标题
DOI：
10.1136/sti.2008.030478
复制
发表时间：
2008-11
影响因子：
3.6
通讯作者：
Mayer K
中科院分区：
文献类型：
--
作者：
Carballo-Diéguez A;Dolezal C;Bauermeister JA;O'Brien W;Ventuneac A;Mayer K
评估男男性行为者 (MSM) 是否更喜欢凝胶或栓剂作为直肠杀菌剂的输送载体。 77 名近期在接受性肛交 (RAI) 期间不一致使用安全套的 HIV 阴性 MSM 承认有感染 HIV 的风险，被纳入一项随机、交叉可接受性试验。他们将 35 毫升安慰剂凝胶与 8 克安慰剂直肠栓剂进行了最多 3 次 RAI 场合的比较。参与者更喜欢凝胶而不是栓剂（75% vs. 25%，p <.001），他们的伴侣也是如此（71% vs. 29%，p <.001）。该凝胶总体上以及在颜色、气味、稠度、插入后立即和/或插入后 30 分钟后直肠内的感觉以及应用过程等属性上获得了更有利的评价。该凝胶在参与者因渗漏、弄脏、腹胀、胀气、胃痉挛、排便冲动、腹泻、疼痛或创伤而困扰的方面减少了负面评价。参与者在肛交时的感觉、性满意度、伴侣的性满意度以及使用安全套和不使用安全套时对产品的喜欢程度方面更喜欢凝胶。在这个取自最有可能受益于直肠杀菌剂可用性的人群之一的样本中，凝胶作为潜在杀菌剂载体比栓剂具有更高的可接受性。
To assess whether men who have sex with men (MSM) prefer a gel or a suppository as a delivery vehicle for a rectal microbicide. 77 HIV-negative MSM with recent history of inconsistent condom use during receptive anal intercourse (RAI) who acknowledged being at risk of contracting HIV were enrolled in a randomized, crossover acceptability trial. They compared 35 ml of placebo gel with 8 g placebo rectal suppositories used in up to three RAI occasions each. Participants preferred the gel over the suppository (75% vs. 25%, p <.001), and so did their partners (71% vs. 29%, p <.001). The gel received more favorable ratings overall and on attributes such as color, smell, consistency, feeling in rectum immediately after insertion and/or 30 minutes after insertion, and application process. The gel resulted in less negative ratings in terms of participants being bothered by leakage, soiling, bloating, gassiness, stomach cramps, urge to have bowel movement, diarrhea, pain or trauma. Participants liked the gel more in terms of feelings during anal sex, sexual satisfaction, partners’ sexual satisfaction, and liking the product when condoms were used and when condoms were not used. In this sample taken from one of the populations most likely to benefit from rectal microbicide availability, gel had higher acceptability than suppository as a potential microbicide vehicle.
登录
查看更多内容
影响因子：
3.1
作者：
Carballo-Dieguez, Alex;Exner, Theresa;Mayer, Kenneth H.
通讯作者：
Mayer, Kenneth H.
影响因子：
4.4
作者：
Carballo-Dieguez, Alex;Bauermeister, Jose A.;Remien, Robert H.
通讯作者：
Remien, Robert H.
影响因子：
4.4
作者：
Morrow, Kathleen M.;Ruiz, Monica S.
通讯作者：
Ruiz, Monica S.
影响因子：
12.7
作者：
Carballo-Diéguez, A;Stein, Z;Díaz, F
通讯作者：
Díaz, F
影响因子：
3.1
作者：
Gross, M;Buchbinder, SP;Seage, GR
通讯作者：
Seage, GR