Quantification of the edge effect in calcified bioprosthetic tissues.

Quantification of the edge effect in calcified bioprosthetic tissues.
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钙化生物假体组织边缘效应的量化。

DOI:
10.1002/jbm.820271009
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发表时间:
1993
期刊:
Journal of biomedical materials research
影响因子:
--
通讯作者:
Harasaki,H
Harasaki,H
中科院分区:
--
文献类型:
--
作者:
Wika,KE;Utoh,J;Brown,J;Harasaki,H

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参考文献

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在植入大鼠皮下空间的生物假体组织样本中,观察到钙化的复发模式。在这种模式中,我们称之为边缘效应,组织内部被钙化,并被无钙化的区域包围并与皮下液体隔开。文献中定性描述了皮下植入物和瓣叶的边缘效应,其可能与这些材料的钙化机制有关。对戊二醛处理的牛心包、甘油处理的牛心包、戊二醛处理的人硬脑膜和甘油处理的人硬脑膜的无钙化外层的厚度进行定量。边缘效应值被认为是独特的和一致的每种材料类型,它们是负相关的收缩温度和材料的钙含量。确定了在确定边缘效应值时,化学处理比组织类型更重要。John Wiley & Sons,Inc.
In bioprosthetic tissue samples that had been implanted in the subcutaneous space of rats, and recurring pattern of calcification was observed. In this pattern, which we call the edge effect, the interior of the tissue is calcified and is surrounded and separated from the subcutaneous fluid by a zone that is free from calcification. The edge effect has been qualitatively described in the literature for subcutaneous implants and for valve leaflets, and it may be related to the mechanism of calcification for these materials. The thickness of the calcification free outer layer was quantified for glutaraldehyde treated bovine pericardium, glycerol treated bovine pericardium, glutaraldehyde treated human dura mater, and glycerol treated human dura mater. The edge effect values were found to be unique and consistent for each material type, and they were inversely related to the shrinkage temperatures and the calcium contents of the materials. It was determined that the chemical treatment was more important than the tissue type in determining the edge effect value. © 1993 John Wiley & Sons, Inc.
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