Properties of Renshaw-like cells excited by recurrent collaterals of pudendal motoneurons in the cat.
Properties of Renshaw-like cells excited by recurrent collaterals of pudendal motoneurons in the cat.
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DOI：
10.1186/s12576-020-00763-0
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发表时间：
2020-07-13
影响因子：
2.3
通讯作者：
Sasaki, Sei-Ichi
中科院分区：
文献类型：
--
作者：
Muramatsu, Ken;Niwa, Masatoshi;Sasaki, Sei-Ichi
尽管解剖学研究表明阴部运动神经元发出复发性侧枝，但它们并不被认为在中间神经元（如Renshaw细胞）上形成突触，而是终止自己的信号。迄今为止，还没有研究检查由阴部运动神经元的复发侧支驱动的中间神经元。在这里，我们的目的是调查的存在Renshaw细胞驱动的阴部运动神经元沿着后者的复发性抑制。从麻醉猫的骶髓腹角获得细胞外记录。背根被切断，运动轴突被电刺激。在Onuf核周围观察到由复发性侧枝循环驱动的Renshaw样细胞，具有短潜伏期放电的高频放电。然而，从阴部运动神经元的细胞内记录没有记录到复发性抑制性突触后电位。总之，我们发现了由阴部运动神经元驱动的Renshaw样细胞，但我们无法识别这些神经元的突触连接。
Although anatomical studies have indicated pudendal motoneurons to give off recurrent collaterals, they are not considered to make synapses onto interneurons, such as Renshaw cells, and rather terminate their own signals. No study till date has examined interneurons being driven by recurrent collaterals of pudendal motoneurons. Here, we aimed to investigate the existence of Renshaw cells driven by pudendal motoneurons along with the recurrent inhibition of the latter. Extracellular recordings were obtained from the ventral horn of the sacral spinal cord of anesthetized cats. Dorsal roots were sectioned, and motor axons were electrically stimulated. Renshaw-like cells driven by recurrent collaterals, with high-frequency firings at short latency discharge, were observed around Onuf’s nucleus. However, the recurrent inhibitory post-synaptic potentials were not recorded by intracellular recordings from the pudendal motoneurons. In summary, we found Renshaw-like cells driven by pudendal motoneurons, but we could not identify the synaptic connection of these neurons.
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