The metabolites of lactic acid bacteria: classification, biosynthesis and modulation of gut microbiota.
The metabolites of lactic acid bacteria: classification, biosynthesis and modulation of gut microbiota.
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乳酸菌的代谢产物：分类，生物合成和肠道菌群的调节。
DOI：
10.15698/mic2023.03.792
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发表时间：
2023-03-06
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乳酸菌是一种普遍存在的微生物，可以在肠道中定植并参与宿主的生理代谢。LAB可以产生多种代谢物，包括有机酸、细菌素、氨基酸、外多糖和维生素。这些代谢物是LAB功能的基础，对宿主健康有着深远的影响。肠道定植了大量具有高度物种多样性的肠道微生物。乳酸菌的代谢物通过帮助维持肠道上皮屏障、抵抗病原体和调节免疫反应，维持肠道菌群的平衡和稳定，进而影响宿主的营养、代谢和行为。本文就乳酸菌的代谢产物及其对肠道的影响作一综述。我们还讨论了潜在的调节机制，并从促进健康的角度强调了乳酸菌与人体肠道之间的联系。
Lactic acid bacteria (LAB) are ubiquitous microorganisms that can colonize the intestine and participate in the physiological metabolism of the host. LAB can produce a variety of metabolites, including organic acids, bacteriocin, amino acids, exopolysaccharides and vitamins. These metabolites are the basis of LAB function and have a profound impact on host health. The intestine is colonized by a large number of gut microorganisms with high species diversity. Metabolites of LAB can keep the balance and stability of gut microbiota through aiding in the maintenance of the intestinal epithelial barrier, resisting to pathogens and regulating immune responses, which further influence the nutrition, metabolism and behavior of the host. In this review, we summarize the metabolites of LAB and their influence on the intestine. We also discuss the underlying regulatory mechanisms and emphasize the link between LAB and the human gut from the perspective of health promotion.
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