Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.
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在组织再生部位的肺居民记忆CD8+ T细胞的特定生态位可实现与CD69无关的维持。
DOI：
10.1084/jem.20160938
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发表时间：
2016-12-12
期刊：
影响因子：
--
通讯作者：
Miyazawa M
中科院分区：
文献类型：
--
作者：
Takamura S;Yagi H;Hakata Y;Motozono C;McMaster SR;Masumoto T;Fujisawa M;Chikaishi T;Komeda J;Itoh J;Umemura M;Kyusai A;Tomura M;Nakayama T;Woodland DL;Kohlmeier JE;Miyazawa M
Takamura等人表明，大多数肺CD 8 + TRM细胞不维持在诱导型支气管相关淋巴组织（iBALT）中，而是维持在组织再生部位产生的特定小生境中，称为修复相关记忆库（RAMD）。CD 8+组织驻留记忆T细胞（TRM细胞）永久驻留在非淋巴组织中，并提供抵抗入侵病原体的第一线保护。然而，CD 8 + TRM细胞在肺中的精确定位仍然不清楚，与其他粘膜相比，肺在生理学上由明显缺乏的增殖组成。在这项研究中，我们发现，肺CD 8 + TRM细胞主要定位于特定的壁龛在组织损伤后的再生部位，而外周组织循环的CD 8+效应记忆T细胞（TEM细胞）广泛但稀疏地分布在未受影响的地区。尽管CD 69抑制鞘氨醇1-磷酸受体1介导的CD 8 + T细胞在招募到肺组织后立即流出，但这种抑制对于TRM龛中细胞的保留是不需要的。此外，尽管TEM细胞与TRM小生境严格分离，但使用同源抗原的引发-拉策略通过创建从头TRM小生境使TEM细胞转化为TRM细胞成为可能。CD 8 + TRM细胞的这种损伤位点特异性定位对于有效保护免受呼吸道病原体的继发感染可能是重要的。
Takamura et al. show that most lung CD8+ TRM cells are not maintained in the inducible bronchus-associated lymphoid tissue (iBALT) but are maintained in specific niches created at the site of tissue regeneration, which are termed as repair-associated memory depots (RAMDs). CD8+ tissue-resident memory T cells (TRM cells) reside permanently in nonlymphoid tissues and provide a first line of protection against invading pathogens. However, the precise localization of CD8+ TRM cells in the lung, which physiologically consists of a markedly scant interstitium compared with other mucosa, remains unclear. In this study, we show that lung CD8+ TRM cells localize predominantly in specific niches created at the site of regeneration after tissue injury, whereas peripheral tissue-circulating CD8+ effector memory T cells (TEM cells) are widely but sparsely distributed in unaffected areas. Although CD69 inhibited sphingosine 1–phosphate receptor 1–mediated egress of CD8+ T cells immediately after their recruitment into lung tissues, such inhibition was not required for the retention of cells in the TRM niches. Furthermore, despite rigid segregation of TEM cells from the TRM niche, prime-pull strategy with cognate antigen enabled the conversion from TEM cells to TRM cells by creating de novo TRM niches. Such damage site–specific localization of CD8+ TRM cells may be important for efficient protection against secondary infections by respiratory pathogens.
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影响因子：
64.5
作者：
Kumar PA;Hu Y;Yamamoto Y;Hoe NB;Wei TS;Mu D;Sun Y;Joo LS;Dagher R;Zielonka EM;Wang de Y;Lim B;Chow VT;Crum CP;Xian W;McKeon F
通讯作者：
McKeon F
树突状细胞对于维持流感病毒感染小鼠肺部的三级淋巴结构至关重要。
DOI：
10.1084/jem.20090410
发表时间：
2009-10-26
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
GeurtsvanKessel CH;Willart MA;Bergen IM;van Rijt LS;Muskens F;Elewaut D;Osterhaus AD;Hendriks R;Rimmelzwaan GF;Lambrecht BN
通讯作者：
Lambrecht BN
影响因子：
4.4
作者：
Hogan, RJ;Usherwood, EJ;Woodland, DL
通讯作者：
Woodland, DL
影响因子：
4.4
作者：
Jelley-Gibbs, Dawn M.;Dibble, John P.;Swain, Susan L.
通讯作者：
Swain, Susan L.
DOI：
10.1073/pnas.1009968107
发表时间：
2010-11-23
影响因子：
11.1
作者：
Grigorova, Irina L.;Panteleev, Mikhail;Cyster, Jason G.
通讯作者：
Cyster, Jason G.