Anxiety Shapes Amygdala-Prefrontal Dynamics During Movie Watching.
Anxiety Shapes Amygdala-Prefrontal Dynamics During Movie Watching.
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DOI：
10.1016/j.bpsgos.2022.03.009
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发表时间：
2023-07
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杏仁核-背内侧前额叶回路被认为是焦虑期间威胁警惕的关键。然而，在相对自然主义的范式中，这种电路的参与仍然没有得到解决。使用开放的功能性磁共振成像数据集（剑桥老龄神经科学中心; n = 630），我们试图调查焦虑是否与电影观看过程中杏仁核和背内侧前额叶皮质之间的动态连接相关。使用主体间表征相似性方法，当比较整部电影中动态连接的成对相似性时，我们没有看到焦虑的影响。然而，预登记的分析表明，焦虑，杏仁核-前额叶动力学，和电影的焦虑功能（规范悬念评级）之间的关系。我们的研究结果表明，杏仁核-前额叶回路调制的悬念在低焦虑的个人，但不太敏感的悬念在高焦虑的个人。我们认为，这也可能与减缓习惯或放大预期有关。此外，一项与威胁相关的注意力偏差（准确性/对恐惧面孔的反应时间）的测量表明与连接性和悬念有关。总的来说，这项研究表明，在观看电影时，焦虑相关的连接差异的存在，随着电影的焦虑特征而变化。从机制上讲，这些差异究竟是如何以及何时出现的，仍然是未来研究的机会。
A well-characterized amygdala–dorsomedial prefrontal circuit is thought to be crucial for threat vigilance during anxiety. However, engagement of this circuitry within relatively naturalistic paradigms remains unresolved. Using an open functional magnetic resonance imaging dataset (Cambridge Centre for Ageing Neuroscience; n = 630), we sought to investigate whether anxiety correlates with dynamic connectivity between the amygdala and dorsomedial prefrontal cortex during movie watching. Using an intersubject representational similarity approach, we saw no effect of anxiety when comparing pairwise similarities of dynamic connectivity across the entire movie. However, preregistered analyses demonstrated a relationship between anxiety, amygdala-prefrontal dynamics, and anxiogenic features of the movie (canonical suspense ratings). Our results indicated that amygdala-prefrontal circuitry was modulated by suspense in low-anxiety individuals but was less sensitive to suspense in high-anxiety individuals. We suggest that this could also be related to slowed habituation or amplified anticipation. Moreover, a measure of threat-relevant attentional bias (accuracy/reaction time to fearful faces) demonstrated an association with connectivity and suspense. Overall, this study demonstrated the presence of anxiety-relevant differences in connectivity during movie watching, varying with anxiogenic features of the movie. Mechanistically, exactly how and when these differences arise remains an opportunity for future research.
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