Threat vigilance and intrinsic amygdala connectivity.

Threat vigilance and intrinsic amygdala connectivity.
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威胁警觉与杏仁核内部连接性

DOI:
10.1002/hbm.25851
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发表时间:
2022-07
影响因子:
4.8
通讯作者:
Robinson, Oliver J.
Robinson, Oliver J.
中科院分区:
医学2区
文献类型:
--
作者:
Kirk, Peter A.;Holmes, Avram J.;Robinson, Oliver J.

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一个有充分文献记载的杏仁核 - 背内侧前额叶回路在理论上被认为可促进对威胁的关注(“威胁警觉”)。先前的研究表明特质焦虑/警觉的个体差异、该回路的参与以及环境的致焦虑特征(例如,通过电击威胁和观看电影)之间存在关联。在本研究中,我们预测——对于那些在自我报告的焦虑和威胁警觉的行为测量中得分较高的人——即使没有致焦虑的刺激,该回路也会长期处于激活状态。然而,我们对静息态功能磁共振成像数据(N = 639)的分析并没有为这种关系提供证据。尽管如此,在我们计划的探索性分析中,我们发现威胁警觉行为(而非自我报告的焦虑)与杏仁核 - 导水管周围灰质的内在连接性之间存在关联。在此,我们认为这种皮质下回路可能在过度警觉的个体中长期处于激活状态,但杏仁核 - 前额叶回路可能仅在对致焦虑刺激作出反应时才被激活。
A well‐documented amygdala‐dorsomedial prefrontal circuit is theorized to promote attention to threat (“threat vigilance”). Prior research has implicated a relationship between individual differences in trait anxiety/vigilance, engagement of this circuitry, and anxiogenic features of the environment (e.g., through threat‐of‐shock and movie‐watching). In the present study, we predicted that—for those scoring high in self‐reported anxiety and a behavioral measure of threat vigilance—this circuitry is chronically engaged, even in the absence of anxiogenic stimuli. Our analyses of resting‐state fMRI data (N = 639) did not, however, provide evidence for such a relationship. Nevertheless, in our planned exploratory analyses, we saw a relationship between threat vigilance behavior (but not self‐reported anxiety) and intrinsic amygdala‐periaqueductal gray connectivity. Here, we suggest this subcortical circuitry may be chronically engaged in hypervigilant individuals, but that amygdala‐prefrontal circuitry may only be engaged in response to anxiogenic stimuli.
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