Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice.
Effect of Goreisan, a Japanese Traditional Medicine, on Cortical Spreading Depolarization in Mice.
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DOI：
10.3390/ijms232213803
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发表时间：
2022-11-09
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
Goreisan是一种传统的日本汉方药物，通常用于治疗头痛，包括偏头痛;然而，其潜在机制仍然未知。因此，我们研究了Goreisan长期治疗是否会影响偏头痛患者的皮层扩展去极化（CSD）。通过比较用Goreisan处理约3周的动物与具有钾诱导的CSD模型的相应对照之间的CSD阈值、传播速度和CSD频率，在雄性和雌性C57 BL/6小鼠中评估CSD易感性。在用Goreisan长期处理的小鼠和对照小鼠之间未观察到CSD易感性的显著差异。此外，在其他生理参数（包括体重、血气和血压）中未观察到显著差异。CSD敏感性不受Goreisan长期治疗的影响，这表明该药物通过不涉及CSD调节的机制治疗头痛。
Goreisan, a traditional Japanese Kampo medicine, is often used to treat headaches, including migraines; however, the underlying mechanisms remain unknown. Therefore, we investigated whether chronic treatment with Goreisan affects cortical spreading depolarization (CSD) in migraines. CSD susceptibility was assessed in male and female C57BL/6 mice by comparing CSD threshold, propagation velocity, and CSD frequency between animals treated with Goreisan for approximately 3 weeks and the corresponding controls with a potassium-induced CSD model. No significant differences were observed in CSD susceptibility between mice that were chronically treated with Goreisan and the control mice. Additionally, no significant differences were observed in other physiological parameters, including body weight, blood gases, and blood pressure. CSD susceptibility was not affected by chronic treatment with Goreisan, which suggests that the drug treats headaches via mechanisms that do not involve CSD modulation.
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DOI：
10.1016/s1474-4422(18)30387-9
发表时间：
2018-12
期刊：
The Lancet. Neurology
影响因子：
--
作者：
GBD 2016 Meningitis Collaborators
通讯作者：
GBD 2016 Meningitis Collaborators
DOI：
10.1155/2017/3209219
发表时间：
2017
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Yano Y;Yano H;Takahashi H;Yoshimoto K;Tsuda S;Fujiyama K;Izumo-Shimizu Y;Motoie R;Ito M;Tanaka J;Ishii E;Fukuda M
通讯作者：
Fukuda M
影响因子：
1.8
作者：
Takiyama，Mikina;Matsumoto，Takashi;Mizoguchi，Kazushige
通讯作者：
Mizoguchi，Kazushige
影响因子：
3.7
作者：
Chung, David Y.;Sadeghian, Homa;Ayata, Cenk
通讯作者：
Ayata, Cenk
DOI：
10.1186/s10194-022-01384-1
发表时间：
2022-01-21
期刊：
The journal of headache and pain
影响因子：
--
作者：
Liu TT;Morais A;Takizawa T;Mulder I;Simon BJ;Chen SP;Wang SJ;Ayata C;Yen JC
通讯作者：
Yen JC