Protective Effect of Antioxidants in Nitric Oxide/COX-2 Interaction during Inflammatory Pain: The Role of Nitration.
Protective Effect of Antioxidants in Nitric Oxide/COX-2 Interaction during Inflammatory Pain: The Role of Nitration.
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DOI：
10.3390/antiox9121284
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发表时间：
2020-12-16
期刊：
影响因子：
--
通讯作者：
Muscoli C
中科院分区：
文献类型：
--
作者：
Ilari S;Dagostino C;Malafoglia V;Lauro F;Giancotti LA;Spila A;Proietti S;Ventrice D;Rizzo M;Gliozzi M;Palma E;Guadagni F;Salvemini D;Mollace V;Muscoli C
In clinical practice, inflammatory pain is an important, unresolved health problem, despite the utilization of non-steroidal anti-inflammatory drugs (NSAIDs). In the last decade, different studies have proven that reactive oxygen species (ROS) and reactive nitrogen species (RNS) are involved in the development and maintenance of inflammatory pain and hyperalgesia via the post-translation modification of key proteins, such as manganese superoxide dismutase (MnSOD). It is well-known that inducible cyclooxygenase 2 (COX-2) plays a crucial role at the beginning of the inflammatory response by converting arachidonic acid into proinflammatory prostaglandin PGE2 and then producing other proinflammatory chemokines and cytokines. Here, we investigated the impact of oxidative stress on COX-2 and prostaglandin (PG) pathways in paw exudates, and we studied how this mechanism can be reversed by using antioxidants during hyperalgesia in a well-characterized model of inflammatory pain in rats. Our results reveal that during the inflammatory state, induced by intraplantar administration of carrageenan, the increase of PGE2 levels released in the paw exudates were associated with COX-2 nitration. Moreover, we showed that the inhibition of ROS with Mn (III) tetrakis (4-benzoic acid) porphyrin(MnTBAP) antioxidant prevented COX-2 nitration, restored the PGE2 levels, and blocked the development of thermal hyperalgesia.
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影响因子：
4.8
作者：
Doyle, Tim;Chen, Zhoumou;Salvemini, Daniela
通讯作者：
Salvemini, Daniela
脊髓 NADPH 氧化酶是吗啡引起的痛觉过敏和镇痛耐受中超氧化物的来源。
影响因子：
2.5
作者：
Doyle, Tim;Bryant, Leesa;Muscoli, Carolina;Cuzzocrea, Salvatore;Esposito, Emanuela;Chen, Zhoumou;Salvemini, Daniela
通讯作者：
Salvemini, Daniela
DOI：
10.1080/01635581.2018.1446091
发表时间：
2018-04
期刊：
Nutrition and cancer
影响因子：
--
作者：
Desai SJ;Prickril B;Rasooly A
通讯作者：
Rasooly A
影响因子：
4.6
作者：
de Paula, Tiago Dal-Cin;Silva, Bruno R.;Bendhack, Lusiane Maria
通讯作者：
Bendhack, Lusiane Maria
氧化应激和炎症：多酚可以为我们做什么？
影响因子：
--
作者：
Hussain T;Tan B;Yin Y;Blachier F;Tossou MC;Rahu N
通讯作者：
Rahu N