Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer.
Mechanisms of Phytonutrient Modulation of Cyclooxygenase-2 (COX-2) and Inflammation Related to Cancer.
复制标题
DOI：
10.1080/01635581.2018.1446091
复制
发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Rasooly A
中科院分区：
文献类型：
--
作者：
Desai SJ;Prickril B;Rasooly A
慢性炎症和癌症之间的联系涉及细胞因子和炎症途径的介体。环氧合酶-2(COX-2)是脂肪酸代谢的关键酶，在炎症和癌症过程中表达上调。COX-2ιS在炎症部位诱导促炎细胞因子和增强COX-2诱导的前列腺素合成，促进癌细胞增殖，促进血管生成，抑制细胞凋亡，增加转移潜能。因此，环氧合酶-2抑制剂成为潜在临床应用的研究热点。流行病学研究强调了富含植物营养素的饮食对癌症预防的潜在好处。植物含有大量的植物营养次生代谢物，可以调节COX-2。研究表明，这些代谢物，其中一些用于传统医学，可以减少炎症和癌症的发生。本文综述了植物营养素调节炎症的分子机制，包括针对与癌症相关的各种炎症相关分子和途径的类胡萝卜素、酚类化合物和脂肪酸的研究。途径的例子包括COX-2、MEKK、MAPK、促炎细胞因子和转录因子，如NF-κB。这种对COX-2和炎症的植物营养调节在癌症的预防和治疗中的应用继续被探索。
The link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways. Cyclooxygenase-2 (COX-2), a key enzyme in fatty acid metabolism, is upregulated during both inflammation and cancer. COX-2 ιs induced by proinflammatory cytokines at the site of inflammation and enhanced COX-2-induced synthesis of prostaglandins stimulates cancer cell proliferation, promotes angiogenesis, inhibits apoptosis and increases metastatic potential. As a result COX-2 inhibitors are a subject of intense research interest toward potential clinical applications. Epidemiological studies highlight the potential benefits of diets rich in phytonutrients for cancer prevention. Plants contain numerous phytonutrient secondary metabolites shown to modulate COX-2. Studies have shown that these metabolites, some of which are used in traditional medicine, can reduce inflammation and carcinogenesis. This review describes the molecular mechanisms by which phytonutrients modulate inflammation, including studies of carotenoids, phenolic compounds and fatty acids targeting various inflammation-related molecules and pathways associated with cancer. Examples of pathways include those of COX-2, MEKK, MAPK, pro-inflammatory cytokines, and transcription factors like NF-κB. Such phytonutrient modulation of COX-2 and inflammation continue to be explored for applications in the prevention and treatment of cancer.
登录
查看更多内容
影响因子：
7.1
作者：
Braem, Marieke G. M.;Onland-Moret, N. Charlotte;Peeters, Petra H. M.
通讯作者：
Peeters, Petra H. M.
影响因子：
6.3
作者：
Camuesco, D.;Comalada, M.;Galvez, J.
通讯作者：
Galvez, J.
影响因子：
7
作者：
Calder, Philip C.
通讯作者：
Calder, Philip C.
影响因子：
4.8
作者：
Carter, AB;Knudtson, KL;Hunninghake, GW
通讯作者：
Hunninghake, GW
影响因子：
3.1
作者：
Bismark, Rashmi S.;Chen, Hongbin;Mahoney, Martin C.
通讯作者：
Mahoney, Martin C.