MiR-29b is associated with perinatal inflammation in extremely preterm infants.
MiR-29b is associated with perinatal inflammation in extremely preterm infants.
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MiR-29b与极早产儿围产期炎症相关。
DOI：
10.1038/s41390-020-0943-1
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发表时间：
2021-03
影响因子：
3.6
通讯作者：
Rogers LK
中科院分区：
文献类型：
--
作者：
Pavlek LR;Vudatala S;Bartlett CW;Buhimschi IA;Buhimschi CS;Rogers LK
炎症与早产和新生儿发病率密切相关。婴儿触珠蛋白（Hp和HRP）和IL-6水平的增加是羊膜内炎症（IAI）的指标，并与不良的新生儿结局有关。炎症引起表观遗传变化，特别是抑制miR-29表达。目前的研究试图确定脐带血或新生儿静脉血中的miR-29 b水平是否与IAI相关，通过升高的IL-6和触珠蛋白以及婴儿随后的临床发病率来确定。我们检测了92份早产儿脐带血样本和18份校正胎龄为36周的静脉血样本。PCR法检测miR-29 b，ELISA法检测Hp和Hp结合珠蛋白（HpRP），ELISA法检测IL-6。在暴露于IAI且Hp& HRP和IL-6水平升高的婴儿中以及在自发性早产的婴儿中观察到miR-29 b水平降低。在诊断为组织学绒毛膜炎或精索炎的女性和脑瘫婴儿中也观察到较低的miR-29水平。在小于胎龄儿（SGA）和年龄较大婴儿的静脉样本中测量到较高水平的miR-29。miR-29可能是IAI的另一个生物标志物，也是治疗产前暴露于IAI导致的新生儿不良结局的潜在治疗靶点。
Inflammation is strongly associated with premature birth and neonatal morbidities. Increases in infant haptoglobin (Hp&HpRP) and IL-6 levels are indicators of intra-amniotic inflammation (IAI) and have been linked to poor neonatal outcomes. Inflammation causes epigenetic changes, specifically suppression of miR-29 expression. The current study sought to determine whether miR-29b levels in cord blood or neonatal venous blood are associated with IAI, identified by elevated IL-6 and haptoglobin, and subsequent clinical morbidities in the infant. We tested 92 cord blood samples from premature newborns and 18 venous blood samples at 36 weeks corrected gestational age. MiR-29b, haptoglobin (Hp&HpRP), and IL-6 were measured by PCR and ELISA respectively. Decreased levels of miR-29b were observed in infants exposed to IAI with elevated Hp&HpRP and IL-6 levels and in infants delivered by spontaneous preterm birth. Lower miR-29 levels were also observed in women diagnosed with histological chorioamnionitis or funisitis and in infants with cerebral palsy. Higher levels of miR-29 were measured in infants small for gestational age (SGA) and in venous samples from older infants. MiR-29 may be an additional biomarker of IAI and a potential therapeutic target for treating poor newborn outcomes resulting from antenatal exposure to IAI.
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影响因子：
2.3
作者：
Rabbee, N;Coull, BA;Senchaudhuri, P
通讯作者：
Senchaudhuri, P
影响因子：
2
作者：
Patel RM
通讯作者：
Patel RM
影响因子：
2.1
作者：
Nuyt, Anne Monique;Lavoie, Jean-Claude;Luu, Thuy Mai
通讯作者：
Luu, Thuy Mai
影响因子：
5.1
作者：
MENT, LR;DUNCAN, CC;GETTNER, P
通讯作者：
GETTNER, P
DOI：
10.1111/j.1471-0528.2008.01925.x
发表时间：
2009-01
期刊：
BJOG : an international journal of obstetrics and gynaecology
影响因子：
--
作者：
Buhimschi CS;Dulay AT;Abdel-Razeq S;Zhao G;Lee S;Hodgson EJ;Bhandari V;Buhimschi IA
通讯作者：
Buhimschi IA