Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease?
Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease?
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DOI：
10.3389/fimmu.2018.02099
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发表时间：
2018
影响因子：
7.3
通讯作者：
Nares S
中科院分区：
文献类型：
--
作者：
Naqvi AR;Shango J;Seal A;Shukla D;Nares S
口腔不断遇到过多的微生物。有效和高效的口腔先天性和适应性免疫应答是维持健康粘膜的必要条件。人类疱疹病毒（HHV）是一种大包膜DNA病毒家族，在多种口腔炎性疾病中的患病率较高，表明其参与疾病进展。然而，导致口腔疾病的病毒成分仍然不清楚。microRNA（miRNA）是非蛋白质编码的单链核糖核酸（RNA）分子，其在转录后调节多种信使RNA。因此，miRNA可以控制大量的生物过程。miRNA表达的变化与各种口腔感染和疾病有关。细胞miRNA可以作为促病毒或抗病毒因子，并且在疱疹病毒感染期间发生宿主miRNA表达的失调。这强烈表明细胞miRNA在宿主与疱疹病毒相互作用中发挥着关键作用。有趣的是，HHV还编码多种miRNA（称为病毒miRNA），这些miRNA可能通过调节宿主生物学途径和控制病毒生命周期在宿主-病原体相互作用中发挥关键作用。我们实验室最近的研究已经在患病的口腔组织活检中鉴定了病毒miRNAs（v-miRs），并证明了它们的免疫调节作用。本文综述了miRNAs（包括宿主和病毒）与疱疹病毒在口腔炎症性疾病发病机制中的关系。
The oral cavity incessantly encounters a plethora of microorganisms. Effective and efficient oral innate and adaptive immune responses are incumbent to maintain healthy mucosa. A higher prevalence of Human Herpesviruses (HHV), a family of large enveloped DNA viruses, has been reported in multiple oral inflammatory diseases suggesting their involvement in disease progression. However, the viral components contributing to oral disease remain obscure. MicroRNAs (miRNA) are non-protein coding, single stranded ribonucleic acid (RNA) molecules that post-transcriptionally regulate diverse messenger RNAs. Thus, miRNAs can control large repertoire of biological processes. Changes in miRNA expression are associated with various oral infections and diseases. Cellular miRNAs can act as pro- or anti-viral factors and dysregulation of host miRNA expression occurs during herpesviruses infection. This strongly suggest a critical role of cellular miRNAs in host-herpesvirus interaction. Interestingly, HHV also encode multiple miRNAs (called viral miRNAs) that may play key role in host-pathogen interaction by modulating both host biological pathways and controlling viral life cycle. Recent studies from our laboratory have identified viral miRNAs (v-miRs) in diseased oral tissue biopsies and demonstrate their immunomodulatory roles. This review discusses the association of miRNAs (both host and viral) and herpesviruses in the pathogenesis of oral inflammatory diseases.
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作者：
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DOI：
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