Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair.
Cyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair.
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DOI：
10.1038/s41467-023-39605-z
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发表时间：
2023-08-04
影响因子：
16.6
通讯作者：
Tsuji, Takashi
中科院分区：
文献类型：
--
作者：
Takeo, Makoto;Toyoshima, Koh-ei;Fujimoto, Riho;Iga, Tomoyo;Takase, Miki;Ogawa, Miho;Tsuji, Takashi
生物节律参与几乎所有类型的生物过程，不仅是生理过程，而且形态发生。目前，多细胞生物体中组织/器官的周期性形态模式是如何形成的尚未完全了解。在这里，使用具有3个弯曲的小鼠之字形毛发，我们发现毛祖细胞和它们的微生态位的组合的变化以及随后的弯曲形成每三天发生一次。Ptn和Aff 3的嵌合功能丧失和功能获得（其在弯曲形成之前立即上调）导致在体内毛发重建测定中微生态位的向下运动和弯曲形成的节律的缺陷。我们的研究表明，祖先和微生态位之间的组合的周期性变化，这是至关重要的独特的亚昼夜节律。生物节律影响生理和形态发生，但这些如何影响周期性模式的形成仍不清楚。在这里，作者表明，在锯齿形头发中观察到的亚昼夜节律是由毛祖细胞和它们的微生态位调节的，并影响毛干弯曲。
Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multicellular organisms form is not fully understood. Here, using mouse zigzag hair, which has 3 bends, we found that a change in the combination of hair progenitors and their micro-niche and subsequent bend formation occur every three days. Chimeric loss-of-function and gain-of-function of Ptn and Aff3, which are upregulated immediately before bend formation, resulted in defects in the downward movement of the micro-niche and the rhythm of bend formation in an in vivo hair reconstitution assay. Our study demonstrates the periodic change in the combination between progenitors and micro-niche, which is vital for the unique infradian rhythm. Biological rhythms influence physiology and morphogenesis, though how these influence periodic pattern formation remains unclear. Here the authors show that the infradian rhythm observed in zigzag hairs is regulated by hair progenitors and their micro-niche and influences hair shaft bending.
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影响因子：
4.5
作者：
Lin KK;Kumar V;Geyfman M;Chudova D;Ihler AT;Smyth P;Paus R;Takahashi JS;Andersen B
通讯作者：
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