Impaired plasma membrane glycoprotein assembly in the liver following acute ethanol administration.

Impaired plasma membrane glycoprotein assembly in the liver following acute ethanol administration.
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急性乙醇给药后肝脏质膜糖蛋白组装受损。

DOI:
10.1016/s0006-291x(84)80226-0
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发表时间:
1984
影响因子:
3.1
通讯作者:
Tuma,DJ
Tuma,DJ
中科院分区:
生物学4区
文献类型:
--
作者:
Mailliard,ME;Sorrell,MF;Volentine,GD;Tuma,DJ

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在大鼠体内研究了急性乙醇给药对肝质膜组装的影响。当在急性剂量的乙醇后注射[14 C]岩藻糖和[3 H] N-乙酰甘露糖胺(一种唾液酸前体)时,观察到对岩藻糖的影响极小,并且唾液酸掺入肝膜糖蛋白总池的量略有减少。然而,标记的岩藻糖蛋白和唾液酸蛋白到质膜中的组装在乙醇处理的动物中被显著抑制。这些结果表明,乙醇的管理损害膜组装的后期阶段,其中包括运输的糖蛋白从高尔基复合体的质膜和/或糖蛋白插入到膜。
The in vivo effects of acute ethanol administration on hepatic plasma membrane assembly were studied in the rat. When [14C] fucose and [3H]N-acetylmannosamine, a sialic acid precursor, were injected following an acute dose of ethanol, minimal effects on fucose and a slight reduction of sialic acid incorporation into the total pool of hepatic membrane glycoproteins were observed. However, the assembly of labeled fucoproteins and sialoproteins into the plasma membrane was markedly inhibited in the ethanol-treated animals. These results indicate that ethanol administration impairs the late stages of membrane assembly which include the transport of glycoproteins from the Golgi complex to the plasma membrane and/or the insertion of glycoproteins into the membrane.
L-岩藻糖掺入大鼠肝脏高尔基体和血清中的糖蛋白。
DOI: --
发表时间: 1973
期刊: Biochimica et Biophysica Acta
影响因子: --
作者:
J. Sturgess;E. Minaker;M. Mitranic;M. Moscarello
通讯作者: M. Moscarello
DOI: 10.1016/s0021-9258(18)50284-2
发表时间: 1979
期刊: The Journal of biological chemistry
影响因子: --
作者:
J. Chan;N. Nwokoro;H. Schachter
通讯作者: H. Schachter
乙醇对大鼠肝蛋白质合成和分泌的急性影响。
DOI: --
发表时间: 1980
期刊: Gastroenterology
影响因子: 29.4
作者:
E. Baraona;P. Pikkarainen;M. Salaspuro;Frances Finkelman;C. Lieber
通讯作者: C. Lieber
DOI: 10.1016/0005-2736(81)90465-x
发表时间: 1981-01-01
期刊: BIOCHIMICA ET BIOPHYSICA ACTA
影响因子: --
作者:
ODA, K;IKEHARA, Y
通讯作者: IKEHARA, Y
DOI: 10.1042/bj1920903
发表时间: 1980
期刊: The Biochemical journal
影响因子: --
作者:
W. H. Evans;N. Flint;P. Vischer
通讯作者: P. Vischer