What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens.
What is and what should always have been: long-lived plasma cells induced by T cell-independent antigens.
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DOI：
10.4049/jimmunol.1300161
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发表时间：
2013-06-15
期刊：
影响因子：
--
通讯作者：
Allman D
中科院分区：
文献类型：
--
作者：
Bortnick A;Allman D
普遍认为抗原诱导的B细胞分化通常导致产生异常长寿的浆细胞。支持这一观点的大部分工作源于集中于在用T细胞依赖性抗原免疫的小鼠中分泌高亲和力同种型转换抗体的生发中心来源的浆细胞的研究。相比之下，较少注意致力于了解T细胞非依赖性抗原和病原体的抗体应答。在这里，我们回顾了最近的工作，表明由多糖或脂多糖组成的T细胞非依赖性抗原也会诱导长寿浆细胞的形成，尽管它们通常无法维持生发中心反应。这一新的信息提供了一个框架，以更充分地了解免疫力的病原体抵抗T细胞识别和细胞外的线索管理浆细胞寿命。
It is well accepted that antigen-induced B cell differentiation often results in the generation of exceptionally long-lived plasma cells. Much of the work supporting this viewpoint stems from studies focused on germinal center-derived plasma cells secreting high-affinity isotype-switched antibodies in mice immunized with T-cell dependent antigens. By contrast, less attention has been devoted to understanding antibody responses to T-cell independent antigens and pathogens. Here we review recent work showing that T-cell independent antigens consisting of either polysaccharides or lipopolysaccharides also induce the formation of long-lived plasma cells, despite their general inability to sustain germinal center responses. This new information provides a framework for more fully understanding the forces underlying immunity to pathogens that resist T cell recognition and the extracellular cues governing plasma cell longevity.
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DOI：
10.1084/jem.194.1.45
发表时间：
2001-07-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Hargreaves DC;Hyman PL;Lu TT;Ngo VN;Bidgol A;Suzuki G;Zou YR;Littman DR;Cyster JG
通讯作者：
Cyster JG
影响因子：
30.5
作者：
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通讯作者：
Weill, Jean-Claude
影响因子：
32.4
作者：
Alugupalli, KR;Leong, JM;Gerstein, RM
通讯作者：
Gerstein, RM
DOI：
10.1084/jem.20080979
发表时间：
2008-12-22
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Choi YS;Baumgarth N
通讯作者：
Baumgarth N
影响因子：
20.3
作者：
Di Genova, G;Roddick, J;Stevenson, FK
通讯作者：
Stevenson, FK