MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells.
MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells.
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DOI：
10.4049/jimmunol.1002825
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发表时间：
2011-05-15
期刊：
影响因子：
--
通讯作者：
Park SH
中科院分区：
文献类型：
--
作者：
Min HS;Lee YJ;Jeon YK;Kim EJ;Kang BH;Jung KC;Chang CH;Park SH
我们最近表明，MHC II 类依赖性胸腺细胞-胸腺细胞 (T-T) 相互作用成功生成 CD4+ T 细胞 (T-T CD4+ T 细胞)，并且表达早幼粒细胞白血病锌指蛋白 (PLZF) 的 T-T CD4+ T 细胞在小鼠和人类中都显示出先天特性。在本文中，我们报道了胸腺 T-T 相互作用对于生理条件下 CD8+ T 细胞向先天表型的转化至关重要。在 PLZF+ CD4+ T 细胞存在下发育的 CD8+ T 细胞显示出中胚层蛋白 (Eomes) 显着上调、激活/记忆表型以及体外刺激时快速产生 IFN-γ。它们的发育高度依赖于T-T CD4+ T细胞中PLZF的表达以及PLZF+ T-T CD4+ T细胞分泌的IL-4。同样的事件也可能发生在人类身上，因为在人类胎儿胸腺和脾脏中发现了大量表达先天 CD8+ T 细胞的 Eomes。这表明PLZF+ T-T CD4+ T细胞与Eomes+ CD8+ T细胞组合可能积极参与针对各种病原体的先天免疫反应，特别是在人类围产期。
We have recently shown that MHC class II-dependent thymocyte–thymocyte (T-T) interaction successfully generates CD4+ T cells (T-T CD4+ T cells), and that T-T CD4+ T cells expressing promyelocytic leukemia zinc finger protein (PLZF) show an innate property both in mice and humans. In this article, we report that the thymic T-T interaction is essential for the conversion of CD8+ T cells into innate phenotype in the physiological condition. CD8+ T cells developed in the presence of PLZF+ CD4+ T cells showed marked upregulation of eomesodermin (Eomes), activation/memory phenotype, and rapid production of IFN-γ on ex vivo stimulation. Their development was highly dependent on the PLZF expression in T-T CD4+ T cells and the IL-4 secreted by PLZF+ T-T CD4+ T cells. The same events may take place in humans, as a substantial number of Eomes expressing innate CD8+ T cells were found in human fetal thymi and spleens. It suggests that PLZF+ T-T CD4+ T cells in combination with Eomes+ CD8+ T cells might actively participate in the innate immune response against various pathogens, particularly in human perinatal period.
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