Intraindividual variability in neural activity in the prefrontal cortex during active walking in older adults.
Intraindividual variability in neural activity in the prefrontal cortex during active walking in older adults.
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DOI：
10.1037/pag0000583
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发表时间：
2020-12
影响因子：
3.7
通讯作者：
Izzetoglu M
中科院分区：
文献类型：
--
作者：
Holtzer R;Ross D;Izzetoglu M
Intra-individual-variability in gait and cognitive performance is distinct from central tendency measures and associated with clinical outcomes in aging. Knowledge concerning intra-individual-variability in neural activity, however, has been relatively scarce; and no research to date has reported on such variability during active walking. The current study addressed this major gap in knowledge. Participants were community-residing older adults (n=394; mean age=76.29±6.65ys; %female=55). functional-Near-Infrared-Spectroscopy (fNIRS) was used to measure oxygenated hemoglobin (HbO2) in the prefrontal cortex under three experimental conditions: Single-Task-Walk, Single-Task-Alpha (cognitive task) and Dual-Task-Walk, which required the participants to perform the two single tasks simultaneously. Intra-individual-variability in neural activity was operationalized using the standard deviation of fNIRS-derived HbO2 observations assessed during a 30-sec interval in each experimental condition. The increase in intra-individual-variability in neural activity in the Dual-Task-Walk condition compared to both single task conditions was associated with the presence of cognitive impairments and being a male. Furthermore, measures of intra-individual-variability in neural activity and gait performance were positively correlated only under the Dual-Task-Walk condition. Intra-individual-variability in neural activity of gait maybe a novel marker for age-related impairments in mobility and cognitive function.
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影响因子：
10.6
作者：
Cools, Roshan;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
影响因子：
4.1
作者：
Fjell, Anders M.;Walhovd, Kristine B.
通讯作者：
Walhovd, Kristine B.
影响因子：
2.6
作者：
Duff, Kevin;Clark, Joy D. Humphreys;Sutker, Patricia B.
通讯作者：
Sutker, Patricia B.
影响因子：
5.5
作者：
Clouston SA;Brewster P;Kuh D;Richards M;Cooper R;Hardy R;Rubin MS;Hofer SM
通讯作者：
Hofer SM
影响因子：
3.4
作者：
Arazi A;Gonen-Yaacovi G;Dinstein I
通讯作者：
Dinstein I