The peripheral and decidual immune cell profiles in women with recurrent pregnancy loss.
The peripheral and decidual immune cell profiles in women with recurrent pregnancy loss.
复制标题
复发性流产妇女外周血和蜕膜免疫细胞的变化
DOI：
10.3389/fimmu.2022.994240
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
Bao, Shihua
中科院分区：
文献类型：
--
作者：
Qin, Dengke;Xu, Huihui;Chen, Zechuan;Deng, Xujing;Jiang, Shan;Zhang, Xiaoming;Bao, Shihua
复发性妊娠丢失（RPL）影响1-2%的育龄夫妇。对RPL患者的免疫状态进行免疫学分析有助于RPL的诊断和治疗。然而，RPL患者的确切免疫细胞组成仍不清楚。在这里，我们使用流式细胞术来研究外周血和蜕膜组织中的免疫细胞分布的妇女谁经历RPL。我们将外周血免疫细胞分为14个主要亚群，RPL患者外周血中T、自然杀伤T（NKT）样细胞和B细胞百分比升高。RPL患者蜕膜免疫细胞可分为14个主要亚群，蜕膜T、NK样细胞和CD 11 chi Mφ的百分比升高，而CD 56 hi NK细胞和CD 11 clo Mφ的百分比降低。斯皮尔曼相关分析表明，外周免疫细胞和蜕膜免疫细胞的比例与既往流产的发生没有显着相关性。通过使用流式细胞术，我们描绘了RPL患者的整体外周和蜕膜免疫景观。外周及蜕膜免疫细胞的异常可能参与了RPL的发生，但与既往流产次数的相关性有待进一步验证。
Recurrent pregnancy loss (RPL) affects 1-2% of couples of reproductive age. Immunological analysis of the immune status in RPL patients might contribute to the diagnosis and treatment of RPL. However, the exact immune cell composition in RPL patients is still unclear. Here, we used flow cytometry to investigate the immune cell profiles of peripheral blood and decidual tissue of women who experienced RPL. We divided peripheral immune cells into 14 major subgroups, and the percentages of T, natural killer T (NKT)-like and B cells in peripheral blood were increased in RPL patients. The decidual immune cells were classified into 14 major subpopulations and the percentages of decidual T, NKT-like cells and CD11chi Mφ were increased, while those of CD56hi decidual NK cells and CD11clo Mφ were decreased in RPL patients. The spearmen correlation analysis showed that the proportion of peripheral and decidual immune cells did not show significant correlations with occurrences of previous miscarriages. By using flow cytometry, we depicted the global peripheral and decidual immune landscape in RPL patients. The abnormalities of peripheral and decidual immune cells may be involved in RPL, but the correlations with the number of previous miscarriages need further verification.
登录
查看更多内容
DOI：
10.1146/annurev-pathmechdis-012418-012743
发表时间：
2019-01-24
期刊：
Annual review of pathology
影响因子：
--
作者：
Deshmukh H;Way SS
通讯作者：
Way SS
成像质量细胞仪揭示了髓样细胞在母体界面界面的重要作用。
影响因子：
5.8
作者：
Krop, Juliette;van der Zwan, Anita;Ijsselsteijn, Marieke E.;Kapsenberg, Hanneke;Luk, Sietse J.;Hendriks, Sanne H.;van der Keur, Carin;Verleng, Lotte J.;Somarakis, Antonis;van der Meeren, Lotte;Haasnoot, Geert;Bos, Manon;de Miranda, Noel F. C. C.;Lopes, Susana M. Chuva de Sousa;van der Hoorn, Marie-Louise P.;Koning, Frits;Claas, Frans H. J.;Heidt, Sebastiaan;Eikmans, Michael
通讯作者：
Eikmans, Michael
树突状细胞亚群在复发性流产中的作用及黄芩苷的调节作用
影响因子：
4.1
作者：
Lai N;Fu X;Hei G;Song W;Wei R;Zhu X;Guo Q;Zhang Z;Chu C;Xu K;Li X
通讯作者：
Li X
影响因子：
3.9
作者：
Janicova A;Becker N;Xu B;Simic M;Noack L;Wagner N;Müller AJ;Bertrand J;Marzi I;Relja B
通讯作者：
Relja B
影响因子：
3.4
作者：
Debreceni, Ildiko Beke;Szasz, Robert;Kappelmayer, Janos
通讯作者：
Kappelmayer, Janos