The early life education of the immune system: Moms, microbes and (missed) opportunities.
The early life education of the immune system: Moms, microbes and (missed) opportunities.
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DOI：
10.1080/19490976.2020.1824564
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发表时间：
2020-11-09
期刊：
影响因子：
12.2
通讯作者：
Jain N
中科院分区：
文献类型：
--
作者：
Jain N
生命早期免疫系统的特点是独特的发育里程碑。功能多样的免疫细胞由不同的造血干细胞波产生，这种现象被称为“分层”免疫。免疫细胞的这种分层发育延伸到先天细胞和适应性细胞的谱系。这些免疫细胞发育的特定时间窗口容易受到生命早期典型的特定暴露的影响。围产期免疫系统是在相对无菌的胎儿环境中发育的，但会出现在充满多种抗原相遇的环境中。其中一个主要负担来自于新生儿粘膜表面新建立的微生物群。越来越多的证据表明，生命早期接触的微生物，包括子宫内产生的微生物，可以给后代的免疫系统留下持久的变化，并决定一生的疾病风险。在这篇综述中，我强调了生命早期免疫的独特特征，并探讨了肠道细菌在教育发育中的免疫系统中的作用。
The early life immune system is characterized by unique developmental milestones. Functionally diverse immune cells arise from distinct waves of hematopoietic stem cells, a phenomenon referred to as ‘layered’ immunity. This stratified development of immune cells extends to lineages of both innate and adaptive cells. The defined time window for the development of these immune cells lends itself to the influence of specific exposures typical of the early life period. The perinatal immune system develops in a relatively sterile fetal environment but emerges into one filled with a multitude of antigenic encounters. A major burden of this comes in the form of the microbiota that is being newly established at mucosal surfaces of the newborn. Accumulating evidence suggests that early life microbial exposures, including those arising in utero, can imprint long-lasting changes in the offspring’s immune system and determine disease risk throughout life. In this review, I highlight unique features of early life immunity and explore the role of intestinal bacteria in educating the developing immune system.
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影响因子：
30.3
作者：
Cahenzli J;Köller Y;Wyss M;Geuking MB;McCoy KD
通讯作者：
McCoy KD
DOI：
10.1126/science.aax6624
发表时间：
2019-10-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Constantinides MG;Link VM;Tamoutounour S;Wong AC;Perez-Chaparro PJ;Han SJ;Chen YE;Li K;Farhat S;Weckel A;Krishnamurthy SR;Vujkovic-Cvijin I;Linehan JL;Bouladoux N;Merrill ED;Roy S;Cua DJ;Adams EJ;Bhandoola A;Scharschmidt TC;Aubé J;Fischbach MA;Belkaid Y
通讯作者：
Belkaid Y
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
5.4
作者：
Cupedo, T;Nagasawa, M;Spits, H
通讯作者：
Spits, H
影响因子：
14.6
作者：
Azad, Meghan B.;Konya, Theodore;Kozyrskyj, Anita L.
通讯作者：
Kozyrskyj, Anita L.