Ultraviolet B Irradiance and Vitamin D Status are Inversely Associated With Incidence Rates of Pancreatic Cancer Worldwide
Ultraviolet B Irradiance and Vitamin D Status are Inversely Associated With Incidence Rates of Pancreatic Cancer Worldwide
复制标题
紫外线 B 辐照度和维生素 D 状况与全球胰腺癌的发病率呈负相关
作者：
S. Mohr;C. Garland;E. Gorham;W. Grant;F. Garland
目的：确定纬度、紫外线B （UVB）辐照度与世界范围内胰腺癌发病率之间是否存在负相关。方法：采用多元线性回归分析UVB照射与胰腺癌发病率之间的关系，同时控制吸烟、饮酒、糖摄入和超重比例。评估血清25-羟基维生素D [25(OH)D]水平，并分析其与发病率的关系。结果：高纬度地区发病率较高（男性纬度R2为0.51,P < 0.001；女性纬度R2为0.32,P < 0.001）。紫外线B辐照度与男性发病率呈独立负相关（P < 0.01），与女性发病率呈负相关（P = 0.02）。饮酒（P < 0.0001）和吸烟（P≤0.01）与男性发病率呈正相关（男性总体模型R2为0.76;P < 0.0001）。酒精（P < 0.0001）和糖（P = 0.001）的摄入与女性发病率呈正相关（女性总体模型R2为0.64;P < 0.0001）。在估计血清25(OH)D浓度为30 ng/mL （75 nmol/L）的国家，发病率比≤30 ng/mL的国家高一半。结论：UVB辐照度较低的国家在两个半球的胰腺癌发病率较高，偶尔有例外。
Objectives: To determine if an inverse association exits between latitude, ultraviolet B (UVB) irradiance and incidence rates of pancreatic cancer worldwide. Methods: Multiple linear regression was used to investigate the relationship and between UVB irradiance incidence rates of pancreatic cancer and while controlling for cigarette, alcohol and sugar consumption, and proportion overweight. Serum 25-hydroxyvitamin D [25(OH)D] levels were estimated, and their association with incidence rates also was analyzed. Results: Incidence rates were higher at higher latitudes (R2 for latitude for men, 0.51; P < 0.001; R2 for latitude for women, 0.32; P < 0.001). Ultraviolet B irradiance also was independently inversely associated with incidence in men (P < 0.01) and women (P = 0.02). Alcohol (P < 0.0001) and cigarette (P ≤ 0.01) consumption were positively associated with incidence in men (R2 for overall model for men, 0.76; P < 0.0001). Alcohol (P < 0.0001) and sugar (P = 0.001) consumption were positively associated with incidence rates in women (R2 for overall model for women, 0.64; P < 0.0001). Incidence rates were half as high in countries with estimated serum 25(OH)D >30 ng/mL (75 nmol/L) than in those with ≤30 ng/mL. Conclusions: Countries with lower UVB irradiance had higher incidence rates of pancreatic cancer in both hemispheres, with occasional exceptions.
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DOI：
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发表时间：
1988
期刊：
The Western journal of medicine
影响因子：
--
作者：
Gorham,ED;Garland,CF;Garland,FC;Benenson,AS;Cottrell,L
通讯作者：
Cottrell,L
影响因子：
11.2
作者：
Stolzenberg-Solomon, Rachael Z.;Vieth, Reinhold;Albanes, Demetrius
通讯作者：
Albanes, Demetrius
影响因子：
158.5
作者：
ADAMS, JS;CLEMENS, TL;HOLICK, MF
通讯作者：
HOLICK, MF
影响因子：
5.8
作者：
MATSUOKA, LY;IDE, L;HOLICK, MF
通讯作者：
HOLICK, MF