Loading of Antibiotics into Polyelectrolyte Multilayers after Self-Assembly and Tunable Release by Catechol Reaction
Loading of Antibiotics into Polyelectrolyte Multilayers after Self-Assembly and Tunable Release by Catechol Reaction
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通过儿茶酚反应自组装和可调释放后将抗生素负载到聚电解质多层中
DOI：
10.1021/acs.jpcc.6b00957
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发表时间：
2016-03
影响因子：
3.7
通讯作者：
Nan Kaihui
中科院分区：
文献类型：
--
作者：
Wang Bailiang;Ye Zi;Tang Yihong;Liu Huihua;Lin Quankui;Chen Hao;Nan Kaihui
细菌在生物医学植入物上的定殖和随后的生物膜的形成通常导致严重的感染。本工作将多巴胺修饰的聚丙烯酸（PAA-dopa）和聚乙烯亚胺（PEI）自组装成多层膜，用于负载和缓释抗生素。将所得多层膜浸入含有硫酸庆大霉素（GS）的Tris缓冲盐水中以负载抗生素，并通过多巴的儿茶酚化学进行交联。通过提高pH值，使PAA中更多的羧基质子化，并通过静电力与GS结合。交联后的多层膜作为药物释放系统，包埋GS的矩阵，显示了两个阶段的持续释放曲线。在体外，GS到磷酸盐缓冲液（PBS）的多层膜，以及抗菌活性的释放，进行了测定。该载药多层膜对金黄色葡萄球菌具有良好的杀菌作用。
The colonization of bacteria on biomedical implants and subsequent forming of biofilm often leads to serious infections. In this work, poly(acrylic acid) modified by dopamine (PAA-dopa) and poly(ethylenimine) (PEI) self-assembled into multilayer films were used to load and for sustained release of antibiotics. The obtained multilayer films were immersed in tris-buffered saline containing gentamicin sulfate (GS) to load the antibiotics and were cross-linked via catechol chemistry of dopa. Through raising pH value, more carboxyl groups of PAA were protonated and combined with GS through electrostatic forces. After cross-linking, the multilayer films were used as a drug delivery system to embed GS in the matrices which showed a two-stage sustained release profile. In vitro, the release of GS into phosphate-buffered saline (PBS) from the multilayer films, as well as the antibacterial activity, was determined. The drug-loaded multilayer films showed excellent bactericidal function against Staphylococcus aureus...
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影响因子：
9.5
作者：
Slomberg, Danielle L.;Lu, Yuan;Schoenfisch, Mark H.
通讯作者：
Schoenfisch, Mark H.
DOI：
10.1002/jbm.b.32841
发表时间：
2013-02
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
N. Fong;L. Poole-Warren;A. Simmons
通讯作者：
N. Fong;L. Poole-Warren;A. Simmons
影响因子：
5.5
作者：
Zhi Xiang Voo;Majad Khan;K. Narayanan;D. Seah;J. Hedrick;Yi Yan Yang
通讯作者：
Zhi Xiang Voo;Majad Khan;K. Narayanan;D. Seah;J. Hedrick;Yi Yan Yang
影响因子：
10.8
作者：
Baeyens, V;Kaltsatos, V;Gurny, R
通讯作者：
Gurny, R
影响因子：
14
作者：
Sze Yinn Wong;Qing Li;J. Veselinovic;Byeong‐Su Kim;A. Klibanov;P. Hammond
通讯作者：
Sze Yinn Wong;Qing Li;J. Veselinovic;Byeong‐Su Kim;A. Klibanov;P. Hammond