Cause of death in adults with Down syndrome in the United States.
Cause of death in adults with Down syndrome in the United States.
复制标题
美国成年人唐氏综合症的死亡原因。
DOI：
10.1016/j.dhjo.2020.100947
复制
发表时间：
2020-10
影响因子：
4.5
通讯作者：
Turk MA
中科院分区：
文献类型：
--
作者：
Landes SD;Stevens JD;Turk MA
先前的研究报告了唐氏综合征成人的异常死亡原因模式，但没有提供唐氏综合征和非唐氏综合征成人之间特定死亡原因的年龄趋势比较，或探讨唐氏综合征成人死亡原因的生物性别和种族-民族差异。为了更好地了解18岁及以上唐氏综合征成年人的死亡趋势。横断面数据来自2013-2017年美国多原因死亡率文件。调整后的比值比用于比较唐氏综合征（N= 9，870）和非唐氏综合征（N= 13，323，001）成人之间的总体和年龄死亡趋势。我们还分析了唐氏综合征成年患者死亡原因的生物学性别和种族-民族差异。虽然心脏病、痴呆症、阿尔茨海默病和癌症在成年人中很常见，但在唐氏综合症患者中，这些疾病的死亡在年轻时更为突出。患有唐氏综合症的成年人也更容易死于流感和肺炎，肺炎，呼吸衰竭和窒息。在唐氏综合征成年患者的死亡原因中存在明显的生物学性别和种族-民族差异。虽然努力减少唐氏综合症成人过早死亡率应注意常见的风险因素，如心脏病，痴呆症和阿尔茨海默病，以及癌症，但必须更加关注这些疾病的早期发病，以及所有年龄段呼吸和吞咽/窒息相关疾病的死亡风险增加。
Prior studies report anomalous cause of death patterns for adults with Down syndrome, but do not provide comparison of age trends for specific causes of death between adults with and without Down syndrome, or explore biological sex and racial-ethnic differences in causes of death among adults with Down syndrome. To better understand cause of death trends for adults, age 18 and over, with Down syndrome. Cross-sectional data were from the 2013–2017 US Multiple Cause of Death Mortality files. Adjusted odds ratios were utilized to compare cause of death trends overall, and by age, between adults with (N=9,870) and without (N=13,323,001) Down syndrome. We also analyzed biological sex and race-ethnic differences in cause of death solely among adults with Down syndrome. Although heart disease, dementia and Alzheimer’s disease, and cancer were common among adults all adults, death from these diseases was more prominent at younger ages for adults with Down syndrome. Adults with Down syndrome were also more likely to die from influenza and pneumonia, pneumonitis, respiratory failure, and choking at all ages. Distinct biological sex and racial-ethnic differences were present in causes of death among adults with Down syndrome. While efforts to reduce premature mortality for adults with Down syndrome should attend to common risk factors such as heart disease, dementia and Alzheimer’s disease, and cancer, it is imperative to afford increased attention to earlier onset of these diseases, as well as increased risk of death from respiratory and swallowing/choking related disorders at all ages.
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影响因子：
5
作者：
MIETTINEN, OS;WANG, JD
通讯作者：
WANG, JD
影响因子：
--
作者：
Hill, DA;Gridley, G;Fraumeni, JF
通讯作者：
Fraumeni, JF
DOI：
10.1111/j.1365-2788.2012.01614.x
发表时间：
2013-12-01
影响因子：
3.6
作者：
Landes, S. D.;Peek, C. W.
通讯作者：
Peek, C. W.
DOI：
10.1016/j.jpeds.2013.06.013
发表时间：
2013-10
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Presson AP;Partyka G;Jensen KM;Devine OJ;Rasmussen SA;McCabe LL;McCabe ER
通讯作者：
McCabe ER
影响因子：
3.3
作者：
Naghavi M;Makela S;Foreman K;O'Brien J;Pourmalek F;Lozano R
通讯作者：
Lozano R