Herceptin-decorated paclitaxel-loaded poly(lactide-co-glycolide) nanobubbles: Ultrasound-facilitated release and targeted accumulation in breast cancers
Herceptin-decorated paclitaxel-loaded poly(lactide-co-glycolide) nanobubbles: Ultrasound-facilitated release and targeted accumulation in breast cancers
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赫赛汀修饰的紫杉醇负载聚丙交酯乙交酯纳米气泡：超声促进释放和乳腺癌中的靶向积累
DOI：
10.1080/10837450.2019.1709500
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发表时间：
2019-12
影响因子：
3.4
通讯作者：
Jie Luo
中科院分区：
文献类型：
--
作者：
Shigen Zhong;Zhiyu Ling;Zhiyi Zhou;Jing He;Haitao Ran;Zhigang Wang;Qunxia Zhang;Weixiang Song;Yong Zhang;Jie Luo
超声可以促进载药物质的药物释放，改变肿瘤局部微环境，促进药物载体向肿瘤组织的转运。基于改变的肿瘤微环境，纳米气泡（NB）作为药物载体，其表面用靶向配体功能化，可以到达肿瘤部位，从而提高化疗的疗效。在本文中，紫杉醇（PTX）负载的聚（丙交酯-共-乙交酯）（PLGA）NB被制备为药物载体，其表面上具有共价缀合的赫赛汀（抗HER 2单克隆抗体）以引导靶点。确定超声对赫赛汀缀合的载药纳米泡（PTXNBs-HER）在癌细胞上的药物释放和靶向的影响。超声的使用显著提高了体外细胞靶向能力和体内渗透性和滞留的增强效率。PTX-NBs-HER与超声的联合应用促进了PTX的释放，以及体外摄取和细胞凋亡。PTX-NB-HER和超声的体内应用增强了PTX在乳腺癌中的靶向和积累，同时减少了PTX在健康器官中的传输和分布。超声与作为造影剂和药物载体的PTX-NBs-HER的结合提供了用于肿瘤精确靶向治疗的图像引导药物递送系统。
Ultrasound can promote the drug release from drug-loaded substances and alter the tumor local microenvironment to facilitate the transport of drug carriers into the tumor tissues. Based on the altered tumor microenvironment, nanobubbles (NBs) as drug carriers with surfaces functionalized with targeting ligands can reach the tumor sites, thereby increasing the efficacy of chemotherapy. Herein,paclitaxel (PTX)-loaded poly(lactide-co-glycolide) (PLGA) NBs are prepared as drug carriers with covalently conjugated herceptin (anti-HER2 monoclonal antibody) on the surface to guide the target. The effect of ultrasound on the drug release and targeting of the herceptin-conjugated drug-loaded nanobubbles (PTXNBs-HER) on the cancerous cells is determined. The use of ultrasound significantly improves the cell targeting capability in vitro and efficiency of enhanced permeability and retention in vivo. The combination of PTX-NBs-HER and ultrasound facilitates the release of PTX, as well as the uptake and cell apoptosis in vitro. The in vivo application of both PTX-NBs-HER and ultrasound enhances the PTX targeting and accumulation in breast cancers while reducing the transmission and distribution of PTX in healthy organs. The combination of ultrasound with PTX-NBs-HER as contrast agents and drug carriers affords an image-guided drug delivery system for the precise targeted therapy of tumors.
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影响因子：
3.8
作者：
Wu ST;Fowler AJ;Garmon CB;Fessler AB;Ogle JD;Grover KR;Allen BC;Williams CD;Zhou R;Yazdanifar M;Ogle CA;Mukherjee P
通讯作者：
Mukherjee P
影响因子：
3.5
作者：
Hussein F;Antonescu C;Karshafian R
通讯作者：
Karshafian R
影响因子：
6
作者：
Kumar, Rishikesh;Sahoo, Ganesh Chandra;Das, Pradeep
通讯作者：
Das, Pradeep
由近红外光触发的温控相变超声成像引导光热化疗
影响因子：
12.4
作者：
Li W;Hou W;Guo X;Luo L;Li Q;Zhu C;Yang J;Zhu J;Du Y;You J
通讯作者：
You J
影响因子：
3.8
作者：
Müller V;Clemens M;Jassem J;Al-Sakaff N;Auclair P;Nüesch E;Holloway D;Shing M;Bang YJ
通讯作者：
Bang YJ