Local immunoglobulin production in nasal tissues: A key to pathogenesis in chronic rhinosinusitis with nasal polyps and aspirin-exacerbated respiratory disease.
Local immunoglobulin production in nasal tissues: A key to pathogenesis in chronic rhinosinusitis with nasal polyps and aspirin-exacerbated respiratory disease.
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鼻组织中局部免疫球蛋白的产生：慢性鼻窦炎伴鼻息肉和阿司匹林加重的呼吸道疾病发病机制的关键
DOI：
10.1016/j.anai.2020.09.016
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Hulse KE
中科院分区：
文献类型：
--
作者：
Buchheit KM;Hulse KE
B细胞的局部活化和抗体产生对于保护性和致病性免疫应答是重要的。也有证据表明，局部活化的B细胞和抗体的生产是重要的慢性鼻窦炎鼻息肉（CRSwNP），这种疾病的严重子集，阿司匹林加重呼吸道疾病（AERD）的发病机制。本文综述了这些发现以及B细胞和抗体在疾病发病机制中的潜在作用。PubMed中的已发表文献检索了与B细胞发育以及B细胞和抗体在CRSwNP和AERD发病机制中的作用相关的研究。三级淋巴结构的形成在B细胞的局部活化和抗体产生中起关键作用。这个过程对于对抗感染很重要，但也会导致自身免疫性疾病。也有证据支持局部B细胞活化和抗体产生在多种过敏性疾病中的作用。来自CRSwNP和AERD患者的鼻息肉组织具有升高水平的活化B细胞亚群和局部产生的抗体。这些局部产生的抗体可能以多种方式促成疾病发病机制，包括先天效应细胞的活化，而局部活化的B细胞可能通过T细胞的活化促成发病机制。需要更多的研究来确定B细胞和抗体在这些患者中驱动疾病的作用。然而，靶向驱动局部B细胞活化和抗体产生的过程可能提供新的治疗方法，并可能有助于减少慢性炎症。
Local activation of B cells and antibody production is important for protective and pathogenic immune responses. There is also evidence that local activation of B cells and antibody production is important in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), and a severe subset of this disease, aspirin-exacerbated respiratory disease (AERD). This review aims to summarize these findings and the potential role of B cells and antibodies in disease pathogenesis. Published literature from PubMed searches Studies relevant to B cell development and to the role of B cells and antibodies in the pathogenesis of CRSwNP and AERD. Formation of tertiary lymphoid structures plays a key role in the local activation of B cells and antibody production. This process is important for fighting infections but also contributes to autoimmune disease. There is also evidence to support a role for local B cell activation and antibody production in a variety of allergic diseases. Nasal polyp tissues from patients with CRSwNP and AERD have elevated levels of activated B cell subsets and locally produced antibodies. These locally produced antibodies may contribute to disease pathogenesis in a variety of ways, including activation of innate effector cells, while locally activated B cells may contribute to pathogenesis through the activation of T cells. More studies are needed to determine the role of B cells and antibodies in driving disease in these patients. However, targeting the processes that drive local B cell activation and antibody production may provide new therapeutic approaches and could help to reduce chronic inflammation.
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DOI：
10.1038/nri3804
发表时间：
2015-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/j.jaci.2016.06.066
发表时间：
2017-04
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Chen JB;James LK;Davies AM;Wu YB;Rimmer J;Lund VJ;Chen JH;McDonnell JM;Chan YC;Hutchins GH;Chang TW;Sutton BJ;Kariyawasam HH;Gould HJ
通讯作者：
Gould HJ
影响因子：
14.2
作者：
Bachert, C;Wagenmann, M;Rudack, C
通讯作者：
Rudack, C
影响因子：
158.5
作者：
Castro, M.;Corren, J.;Teper, A.
通讯作者：
Teper, A.
影响因子：
14.2
作者：
Barternes, KR;Cooper, KM;Kita, H
通讯作者：
Kita, H