Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells.
Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells.
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DOI：
10.1002/cm.21050
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发表时间：
2012-10
期刊：
影响因子：
2.9
通讯作者：
Field, Christine M.
中科院分区：
文献类型：
--
作者：
Mitchison, Timothy;Wuehr, Martin;Phuong Nguyen;Ishihara, Keisuke;Groen, Aaron;Field, Christine M.
雷·拉帕波特花了很多年时间研究微管紫苑，以及它们如何诱导卵裂沟。本文综述了非洲爪蟾和斑马鱼受精卵和早期卵裂球的星状结构和动态的研究进展。有丝分裂期和间期的星状体大小明显不同，只有间期星状体跨越细胞。生长的间期星发生的机制，使微管密度在星周边保持近似恒定的半径增加。我们讨论了紫菀生长的模型，并赞成一个分支成核过程。相邻的紫苑相互作用，在共同的边界上阻止进一步的生长。我们比较的形态相互作用区之间形成的对，从同一有丝分裂纺锤体（姐妹紫苑）的两极和对之间不相关的有丝分裂（非姐妹紫苑），满足多精受精。我们认为，不断增长的紫苑相互承认的相互作用之间的相互作用，在相互边界的反平行微管，并讨论模型的分子组织的相互作用区。最后，我们讨论了如何在他们的中心体，紫苑模型，定位动力蛋白介导的拉力，从而产生刻板的卵裂模式。在超大细胞中研究这些问题，开始揭示细胞组织的一般原理如何随着细胞大小而扩展。
Ray Rappaport spent many years studying microtubule asters, and how they induce cleavage furrows. Here we review recent progress on aster structure and dynamics in zygotes and early blastomeres of Xenopus laevis and Zebrafish, where cells are extremely large. Mitotic and interphase asters differ markedly in size, and only interphase asters span the cell. Growth of interphase asters occurs by a mechanism that allows microtubule density at the aster periphery to remain approximately constant as radius increases. We discuss models for aster growth, and favor a branching nucleation process. Neighboring asters that grow into each other interact to block further growth at the shared boundary. We compare the morphology of interaction zones formed between pairs of asters that grow out from the poles of the same mitotic spindle (sister asters) and between pairs not related by mitosis (non-sister asters) that meet following polyspermic fertilization. We argue growing asters recognize each other by interaction between anti-parallel microtubules at the mutual boundary, and discuss models for molecular organization of interaction zones. Finally, we discuss models for how asters, and the centrosomes within them, are positioned by dynein-mediated pulling forces so as to generate stereotyped cleavage patterns. Studying these problems in extremely large cells is starting to reveal how general principles of cell organization scale with cell size.
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DOI：
10.1083/jcb.84.1.151
发表时间：
1980-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bergen LG;Kuriyama R;Borisy GG
通讯作者：
Borisy GG
影响因子：
3.7
作者：
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4
作者：
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通讯作者：
von Dassow, George
影响因子：
2.5
作者：
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通讯作者：
HIRAMOTO, Y
影响因子：
2.7
作者：
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通讯作者：
VINCENT, JP