APOE, TOMM40, and sex interactions on neural network connectivity.
APOE, TOMM40, and sex interactions on neural network connectivity.
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DOI：
10.1016/j.neurobiolaging.2021.09.020
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发表时间：
2022-01
影响因子：
4.2
通讯作者：
Willette AA
中科院分区：
文献类型：
--
作者：
Li T;Pappas C;Le ST;Wang Q;Klinedinst BS;Larsen BA;Pollpeter A;Lee LY;Lutz MW;Gottschalk WK;Swerdlow RH;Nho K;Willette AA
The Apolipoprotein E ε4 (APOE ε4) haplotype is the strongest genetic risk factor for late-onset Alzheimer‟s disease (AD). The Translocase of Outer Mitochondrial Membrane-40 (TOMM40) gene maintains cellular bioenergetics, which is disrupted in AD. TOMM40 rs2075650 (‘650) G vs. A carriage is consistently related to neural and cognitive outcomes, but it is unclear if and how it interacts with APOE. We examined 21 orthogonal neural networks among 8,222 middle-aged to aged participants in the UK Biobank cohort. ANOVA and multiple linear regression tested main effects and interactions with APOE and TOMM40 ‘650 genotypes, and if age and sex acted as moderators. APOE ε4 was associated with less strength in multiple networks, while ‘650 G vs. A carriage was related to more language comprehension network strength. In APOE ε4 carriers, ‘650 G-carriage led to less network strength with increasing age, while in non G-carriers this was only seen in women but not men. TOMM40 may shift what happens to network activity in aging APOE ε4 carriers depending on sex.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
11
作者：
Davies G;Harris SE;Reynolds CA;Payton A;Knight HM;Liewald DC;Lopez LM;Luciano M;Gow AJ;Corley J;Henderson R;Murray C;Pattie A;Fox HC;Redmond P;Lutz MW;Chiba-Falek O;Linnertz C;Saith S;Haggarty P;McNeill G;Ke X;Ollier W;Horan M;Roses AD;Ponting CP;Porteous DJ;Tenesa A;Pickles A;Starr JM;Whalley LJ;Pedersen NL;Pendleton N;Visscher PM;Deary IJ
通讯作者：
Deary IJ
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
2.5
作者：
Huang, Hao;Zhao, Jun;Chen, Bingwei
通讯作者：
Chen, Bingwei
与阿尔茨海默氏病和脑脊液生物标志物相关的遗传基因座在芬兰病例控制队列中。
影响因子：
3.7
作者：
Elias-Sonnenschein LS;Helisalmi S;Natunen T;Hall A;Paajanen T;Herukka SK;Laitinen M;Remes AM;Koivisto AM;Mattila KM;Lehtimäki T;Verhey FR;Visser PJ;Soininen H;Hiltunen M
通讯作者：
Hiltunen M