Associations between immune-mediated diseases (IMDs) and the risk of HPV-associated diseases: a UK Biobank cohort analysis.
Associations between immune-mediated diseases (IMDs) and the risk of HPV-associated diseases: a UK Biobank cohort analysis.
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DOI：
10.1136/bmjopen-2023-072249
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发表时间：
2023-09-19
期刊：
影响因子：
2.9
通讯作者：
Ren, JianJun
中科院分区：
文献类型：
--
作者：
Feng, Lan;Qiu, Ke;Rao, Yufang;Shu, Tao;Song, Yao;Cheng, Danni;Mao, Minzi;Li, Junhong;Zhang, Ziyan;Wang, Xiaoyu;Zeng, Xinghan;Zhao, Yu;Ren, JianJun
系统评估各种免疫介导疾病（IMD）与人乳头瘤病毒（HPV）相关疾病之间的关系。回顾性队列研究。英国生物样本库。在排除基线时患有HPV相关疾病的受试者和撤回知情同意书或缺乏性别信息的受试者后，共有500 371例年龄在40-69岁之间的受试者有资格进行分析。在英国生物样本库中确定了80个IMD（涉及过敏/特应性疾病、自身免疫性疾病、免疫缺陷疾病等）。主要结局是HPV相关疾病（包括宫颈、口咽、肛门、阴茎、外阴和阴道的疣和恶性肿瘤）的发生率。使用考克斯比例风险模型估计HR和95% CI，特别调整性行为。我们还分别根据HPV相关疾病的良性和恶性状态以及解剖部位进行了亚组分析。在中位数为12.0年的随访中，500 371例受试者中有2244例发生HPV相关疾病。总体而言，在调整性行为和其他潜在混杂因素后，患有IMD的参与者患HPV相关疾病的风险高于其对照组（女性：HR=1.90，95% CI=1.66至2.17，p<0.001;男性：HR=1.66，95% CI=1.41至1.97，p<0.001）。此外，8例女性IMD（如哮喘：HR=1.76，95% CI=1.47 - 2.11，p<0.001）和3例男性IMD（如慢性肾炎综合征：HR=6.05，95% CI=3.32 - 11.04，p<0.001）与HPV相关疾病风险增加相关。亚组分析显示，良性和恶性亚组之间以及口咽和肛门生殖器亚组之间的IMD存在显著差异。在这项大型回顾性队列研究中，IMD与HPV相关疾病的风险升高显著相关。此外，还观察到个体IMD与HPV相关疾病之间的性别特异性和区域特异性关联。
To systematically assess the associations between various immune-mediated diseases (IMDs) and human papillomavirus (HPV)-associated diseases. Retrospective cohort study. UK Biobank. A total of 500 371 subjects aged 40–69 years were eligible for the analysis, after excluding those with prevalent HPV-associated diseases at baseline and those who had withdrawn their informed consent or lacked information on sex. Eighty IMDs (involving allergic/atopic diseases, autoimmune diseases, immunodeficiency diseases, etc) were identified in the UK Biobank. The main outcome was the incidence of HPV-associated diseases (including warts and malignancies of the cervix, oropharynx, anus, penis, vulva and vagina). Cox proportional hazards model was used to estimate HRs and 95% CIs with particular adjustment for sexual behaviours. We also conducted subgroup analyses based on benign and malignant status, and anatomical sites of HPV-associated diseases, respectively. During a median of 12.0 years of follow-up, 2244 cases out of 500 371 subjects developed HPV-associated diseases. Overall, participants with IMDs had a higher risk of HPV-associated diseases than their controls after adjustment for sexual behaviours and other potential confounders (female: HR=1.90, 95% CI=1.66 to 2.17, p<0.001; male: HR=1.66, 95% CI=1.41 to 1.97, p<0.001). Additionally, eight individual IMDs in women (eg, asthma: HR=1.76, 95% CI=1.47 to 2.11, p<0.001) and three in men (eg, chronic nephritic syndrome: HR=6.05, 95% CI=3.32 to 11.04, p<0.001) were associated with increased risk of HPV-associated diseases. Subgroup analyses revealed significant IMD differences between benign and malignant subgroups as well as between oropharyngeal and anogenital subgroups. In this large retrospective cohort study, IMDs were significantly associated with an elevated risk of HPV-associated diseases. Besides, gender-specific and region-specific associations were also observed between individual IMDs and HPV-associated diseases.
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影响因子：
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作者：
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