RNA polymerase and the ribosome: the close relationship.

RNA polymerase and the ribosome: the close relationship.
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DOI:
10.1016/j.mib.2013.01.010
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发表时间:
2013-04
影响因子:
5.4
通讯作者:
Nudler E
Nudler E
中科院分区:
生物学2区
文献类型:
--
作者:
McGary K;Nudler E

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在细菌中,转录和翻译在时间和空间上是联系在一起的。当与RNA聚合酶(RNAP)偶联时,翻译核糖体通过防止RNAP回溯来确保转录持续性。该领域的最新进展已经表征了在转录和翻译之间桥接差距的重要接头蛋白:特别是NusE(S10):NusG复合物和NusG同系物RfaH。移动的核糖体和RNAP之间的直接联系为保持基因组完整性提供了基础,同时使细菌细胞内的各种基因能够有效转录和及时翻译。
In bacteria transcription and translation are linked in time and space. When coupled to RNA polymerase (RNAP), the translating ribosome ensures transcriptional processivity by preventing RNAP backtracking. Recent advances in the field have characterized important linker proteins that bridge the gap between transcription and translation: In particular, the NusE(S10):NusG complex and the NusG homolog, RfaH. The direct link between the moving ribosome and RNAP provides a basis for maintaining genomic integrity while enabling efficient transcription and timely translation of various genes within the bacterial cell.
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